Department of Obstetrics and Gynecology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.
Research Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Int Urogynecol J. 2024 Mar;35(3):579-588. doi: 10.1007/s00192-023-05713-z. Epub 2024 Jan 12.
The objective was to investigate how weight change across and after the childbearing years was associated with urinary incontinence (UI) in midlife.
Data were obtained from 35,645 women responding to the Maternal Follow-up questionnaire in the Danish National Birth Cohort in 2013-2014. Outcome was self-reported UI and its subtypes. Exposures were changes in body mass index (BMI) across and after the childbearing years. Adjusted odds ratios were estimated using logistic regression.
At follow-up, the mean age was 44 years and 32% experienced UI. Compared with stable weight, weight gain across the childbearing years of > 1 to 3, > 3 to 5 or > 5 BMI units increased the odds of any UI by 15%, 27%, and 41% respectively. For mixed UI, the odds increased by 23%, 41%, and 68% in these groups. Weight gain after childbearing showed the same pattern, but with a higher increase in the odds of mixed UI (25%, 60%, and 95% in the respective groups). Women with any weight loss during this period had 9% lower odds of any UI than women with a stable weight.
Weight gain across and after childbearing increased the risk of UI in midlife, especially the subtype mixed UI. Weight loss after childbearing decreased the risk.
本研究旨在探究生育期前后的体重变化与中年时期尿失禁（UI）的相关性。
数据来自于 2013-2014 年丹麦国家出生队列中 35645 名回应母亲随访问卷的女性。结局为自我报告的 UI 及其亚型。暴露因素为生育期前后的体重指数（BMI）变化。采用逻辑回归估计调整后的比值比。
随访时，平均年龄为 44 岁，32%的女性经历过 UI。与稳定体重相比，生育期体重增加>1 至 3、>3 至 5 或>5 BMI 单位，分别使任何 UI 的几率增加 15%、27%和 41%。对于混合性 UI，这些组别的几率分别增加了 23%、41%和 68%。生育后体重增加也呈现出相同的模式，但混合性 UI 的几率增加更高（分别为 25%、60%和 95%）。在此期间体重减轻的女性发生任何 UI 的几率比体重稳定的女性低 9%。
生育期前后的体重增加会增加中年时期 UI 的风险，尤其是混合性 UI 亚型。生育后体重减轻会降低风险。
