对90个人体内体细胞突变体中的15种重排进行分子特征分析表明，缺失占主导。
Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.
作者信息
Bradley W E, Gareau J L, Seifert A M, Messing K
出版信息
Mol Cell Biol. 1987 Feb;7(2):956-60. doi: 10.1128/mcb.7.2.956-960.1987.
Abstract
Ninety hypoxanthine phosphoribosyltransferase-deficient mutants were isolated from lymphocytes of 31 individuals drawn from both control populations and populations exposed to low doses of ionizing radiation. Southern analysis of the DNA revealed altered hybridization patterns in 15 mutants. Of these, 14 changes consisted of deletions of 2 to 40 kilobases or more.
摘要
从来自对照人群和低剂量电离辐射暴露人群的31个人的淋巴细胞中分离出90个次黄嘌呤磷酸核糖基转移酶缺陷型突变体。对这些突变体DNA的Southern分析显示，15个突变体的杂交模式发生了改变。其中，14处变化包括2至40千碱基或更多碱基的缺失。
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