Department of Chemical Engineering, Samuel Ginn College of Engineering, Auburn University, Auburn, AL, 36849, USA.
Department of Biological Sciences, College of Science and Mathematics, Auburn University, Auburn, AL, 36849, USA.
Cancer Metastasis Rev. 2024 Jun;43(2):823-844. doi: 10.1007/s10555-024-10166-x. Epub 2024 Jan 19.
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and epigenetic modifications to breast cancer progression has been widely acknowledged, emerging evidence underscores the pivotal role of physical stimuli in driving breast cancer metastasis. In this review, we summarize the changes in the mechanics of the breast cancer microenvironment and describe the various forces that impact migrating and circulating tumor cells throughout the metastatic process. We also discuss the mechanosensing and mechanotransducing molecules responsible for promoting the malignant phenotype in breast cancer cells. Gaining a comprehensive understanding of the mechanobiology of breast cancer carries substantial potential to propel progress in prognosis, diagnosis, and patient treatment.
转移是导致绝大多数乳腺癌相关死亡的主要原因。虽然遗传和表观遗传修饰对乳腺癌进展的贡献已得到广泛认可，但新出现的证据强调了物理刺激在推动乳腺癌转移中的关键作用。在这篇综述中，我们总结了乳腺癌微环境力学的变化，并描述了在整个转移过程中影响迁移和循环肿瘤细胞的各种力。我们还讨论了负责促进乳腺癌细胞恶性表型的机械感知和机械转导分子。全面了解乳腺癌的机械生物学具有极大的潜力，可以推动预后、诊断和患者治疗的进展。
