School of Medical, Indigenous and Health Science, University of Wollongong, New South Wales, Australia.
Microbiome Research Centre, University of New South Wales, Kogarah, New South Wales, Australia.
Inflamm Bowel Dis. 2024 Aug 1;30(8):1241-1250. doi: 10.1093/ibd/izad318.
Emulsifiers are implicated in the pathogenesis of inflammatory bowel disease (IBD). Few studies have examined emulsifier intake in people with existing IBD. We aimed to describe the frequency of exposure to 6 selected emulsifiers in a contemporary cohort of people with IBD and compare intake with healthy controls (HCs).
Baseline food records from participants in an Australian prospective cohort study examining the microbiome of IBD patients and HCs were analyzed. Exposure to inflammatory emulsifiers polysorbate-80 (P80); carboxymethylcellulose (CMC); carrageenan; xanthan gum (XG); lecithin (soy and sunflower) and mono- and diglycerides of fatty acids (MDGs) were determined by examining ingredient lists. Frequency of emulsifier exposure between groups (IBD vs HC, Crohn's disease [CD] vs ulcerative colitis [UC], IBD children vs adults, active disease vs remission) was examined after controlling for confounders.
Records from 367 participants were analyzed (n = 176 IBD, of which there were 101 CD, 75 UC, and 191 HC patients). In total, 5022 unique food items were examined, with 18% containing 1 or more emulsifier of interest. Inflammatory bowel disease participants had significantly higher total daily emulsifier exposure compared with HCs (2.7 ± 1.8 vs 2.3 ± 1.6, P = .02). In IBD participants, emulsifiers with the highest daily exposure were MDGs (1.2 ± 0.93), lecithin (0.85 ± 0.93), and XG (0.38 ± 0.42). There were no recorded exposures to P80.
Inflammatory bowel disease participants were exposed to more emulsifiers than HCs. Intake of inflammatory emulsifiers were low or nonexistent, suggesting their presence in the food supply are not as common as frequently stated.
乳化剂与炎症性肠病（IBD）的发病机制有关。很少有研究调查过现有 IBD 患者对乳化剂的摄入量。本研究旨在描述当代 IBD 患者队列中 6 种选定乳化剂的暴露频率，并与健康对照（HC）进行比较。
分析了一项澳大利亚前瞻性队列研究中 IBD 患者和 HC 基线期的食物记录，该研究检查了 IBD 患者的微生物组。通过检查成分表来确定聚山梨醇酯-80（P80）；羧甲基纤维素（CMC）；卡拉胶；黄原胶（XG）；卵磷脂（大豆和葵花籽油）和单双甘油脂肪酸酯（MDG）的暴露情况。在控制混杂因素后，检查了各组（IBD 与 HC、克罗恩病 [CD] 与溃疡性结肠炎 [UC]、IBD 儿童与成人、活动期疾病与缓解期）之间的乳化剂暴露频率。
分析了 367 名参与者的记录（n=176 名 IBD，其中 101 名 CD、75 名 UC 和 191 名 HC 患者）。共检查了 5022 种独特的食物，其中 18%含有 1 种或多种感兴趣的乳化剂。与 HC 相比，IBD 患者的总乳化剂日暴露量显著更高（2.7±1.8 与 2.3±1.6，P=0.02）。在 IBD 患者中，每日摄入量最高的乳化剂为 MDG（1.2±0.93）、卵磷脂（0.85±0.93）和 XG（0.38±0.42）。没有记录到 P80 的暴露。
IBD 患者暴露于乳化剂的频率高于 HC。摄入的炎症性乳化剂含量较低或不存在，这表明它们在食品供应中的存在并不像经常声称的那样普遍。
