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芳樟醇对腐败微生物的抑制机制研究

Studies on the Inhibition Mechanism of Linalyl Alcohol against the Spoilage Microorganism .

作者信息

Wang Longteng, Liu Xing, Chen Wenxue, Sun Zhichang

机构信息

College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou 570228, China.

出版信息

Foods. 2024 Jan 12;13(2):244. doi: 10.3390/foods13020244.

DOI:10.3390/foods13020244
PMID:38254545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10814832/
Abstract

The aim of this study was to investigate the bacterial inhibitory ability and mechanism of action of linalyl alcohol against . Linalyl alcohol causes the leakage of intracellular material by disrupting the cell wall and exposing the hydrophobic phospholipid bilayer, which binds to bacterial membrane proteins and alters their structure. In addition, linalyl alcohol causes cell membrane damage by affecting fatty acids and proteins in the cell membrane. By inhibiting the synthesis of macromolecular proteins, the normal physiological functions of the bacteria are altered. Linalyl alcohol binds to DNA in both grooved and embedded modes, affecting the normal functioning of , as demonstrated through a DNA interaction analysis.

摘要

本研究的目的是探究芳樟醇对……的细菌抑制能力及其作用机制。芳樟醇通过破坏细胞壁并使疏水磷脂双层暴露，导致细胞内物质泄漏，疏水磷脂双层与细菌膜蛋白结合并改变其结构。此外，芳樟醇通过影响细胞膜中的脂肪酸和蛋白质来造成细胞膜损伤。通过抑制大分子蛋白质的合成，细菌的正常生理功能被改变。如通过DNA相互作用分析所证实，芳樟醇以沟槽结合和嵌入两种模式与DNA结合，影响……的正常功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4f/10814832/0f88cd417ad9/foods-13-00244-g011.jpg
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Foods. 2022 Oct 11;11(20):3160. doi: 10.3390/foods11203160.
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Antibacterial activity and mechanism of sanguinarine against by interfering with the permeability of the cell wall and membrane and inducing bacterial ROS production.血根碱通过干扰细胞壁和细胞膜的通透性以及诱导细菌产生活性氧来发挥抗菌活性及其作用机制。
Front Vet Sci. 2023 Mar 30;10:1121082. doi: 10.3389/fvets.2023.1121082. eCollection 2023.
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Antibacterial activity and metabolomic analysis of linalool against bovine mastitis pathogen Streptococcus agalactiae.
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