De Rosa Teresa, Ponticelli Maria, Teta Roberta, Carlucci Vittorio, Milella Luigi, Esposito Germana, Costantino Valeria
The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.
Department of Science, Università Degli Studi Della Basilicata, V.le dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Microorganisms. 2024 Jan 16;12(1):175. doi: 10.3390/microorganisms12010175.
Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we highlight the role of as a producer of unsaturated mono and diacylglycerols, and then demonstrate the antioxidant activity of its methanolic extract, which has as its main components a variety of acylglycerol analogues. This finding was revealed using a sustainable strategy in which the One Strain Many Compounds (OSMAC) cultivation in microscale was coupled with a bioinformatic approach to analyze a large dataset of mass spectrometry data using the molecular networking analyses. This strategy reduces time and costs, avoiding long and expensive steps of purification and obtaining informative data on the metabolic composition of the extracts. This study highlights the role of as a sustainable and green source of novel bioactive compounds.
不饱和二酰基甘油是一类抗氧化化合物,具有对人类健康产生积极影响的潜力。它们通过自由基清除活性对抗氧化应激的能力凸显了其在预防和治疗策略中的重要性。在本文中,我们强调了[具体名称未给出]作为不饱和单酰基甘油和二酰基甘油生产者的作用,然后展示了其甲醇提取物的抗氧化活性,该提取物的主要成分是多种酰基甘油类似物。这一发现是通过一种可持续策略揭示的,其中在微观尺度上的“一种菌株多种化合物”(OSMAC)培养与一种生物信息学方法相结合,使用分子网络分析来分析大量质谱数据。这种策略减少了时间和成本,避免了漫长且昂贵的纯化步骤,并获得了关于提取物代谢组成的信息数据。这项研究强调了[具体名称未给出]作为新型生物活性化合物的可持续和绿色来源的作用。