School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan 2ndRoad, Guangzhou, Guangdong Province, China.
Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
BMC Geriatr. 2022 Jul 26;22(1):620. doi: 10.1186/s12877-022-03311-0.
Existing evidence links hearing loss to depressive symptoms, with the extent of association and underlying mechanisms remaining inconclusive. We conducted a cross-sectional study to examine the association of hearing loss with depressive symptoms and explored whether social isolation mediated the association.
Eight thousand nine hundred sixty-two participants from Guangzhou Biobank Cohort Study were included. Data on self-reported hearing status, the 15-item Geriatric Depression Scale (GDS-15), social isolation and potential confounders were collected by face-to-face interview.
The mean (standard deviation) age of participants was 60.2 (7.8) years. The prevalence of poor and fair hearing was 6.8% and 60.8%, respectively. After adjusting for age, sex, household income, education, occupation, smoking, alcohol use, self-rated health, comorbidities, compared with participants who had normal hearing, those with poor hearing (β = 0.74, 95% confidence interval (CI) 0.54, 0.94) and fair hearing (β = 0.59, 95% CI 0.48, 0.69) had higher scores of GDS-15. After similar adjustment, those with poor hearing (odds ratio (OR) = 2.13, 95% CI 1.65, 2.74) or fair hearing (OR = 1.68, 95% CI 1.43, 1.99) also showed higher odds of depressive symptoms. The association of poor and fair hearing with depressive symptoms attenuated slightly but not substantially after additionally adjusting for social isolation. In the mediation analysis, the adjusted proportion of the association mediated through social isolation was 9% (95% CI: 6%, 22%).
Poor hearing was associated with a higher risk of depressive symptoms, which was only partly mediated by social isolation. Further investigation of the underlying mechanisms is warranted.
现有证据表明听力损失与抑郁症状相关，但关联程度和潜在机制仍不明确。我们进行了一项横断面研究，旨在探讨听力损失与抑郁症状的关系，并探讨社会隔离是否在其中起中介作用。
纳入了来自广州生物银行队列研究的 8962 名参与者。通过面对面访谈收集了自我报告的听力状况、15 项老年抑郁量表（GDS-15）、社会隔离和潜在混杂因素的数据。
参与者的平均（标准差）年龄为 60.2（7.8）岁。听力差和一般的患病率分别为 6.8%和 60.8%。在调整了年龄、性别、家庭收入、教育程度、职业、吸烟、饮酒、自我报告的健康状况、合并症后，与听力正常的参与者相比，听力差（β=0.74，95%置信区间（CI）0.54，0.94）和听力一般（β=0.59，95%CI 0.48，0.69）的 GDS-15 评分更高。在类似的调整后，听力差（比值比（OR）=2.13，95%CI 1.65，2.74）或听力一般（OR=1.68，95%CI 1.43，1.99）的参与者出现抑郁症状的几率也更高。在进一步调整社会隔离后，听力差和一般与抑郁症状的关联略有减弱，但仍有统计学意义。在中介分析中，社会隔离介导的关联比例为 9%（95%CI：6%，22%）。
听力差与抑郁症状的风险增加相关，这种关联部分通过社会隔离来介导。需要进一步研究其潜在机制。
