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桦褐孔菌和微藻提取物对体外哺乳动物癌细胞的协同细胞毒性。

Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro.

机构信息

Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro NS B2N 5E3, Canada.

Adored Beast Apothecary, 77 Rooney Crescent, Moncton NB E1E 4M4, Canada.

出版信息

Oxid Med Cell Longev. 2024 Jan 17;2024:7944378. doi: 10.1155/2024/7944378. eCollection 2024.

DOI:10.1155/2024/7944378
PMID:38268969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10807943/
Abstract

Chaga mushroom () contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from and microalgae using cultured human and canine cancer cell lines (MCF-7, HepG2, HOS, D-17, and DH-82). MTS cell viability assay was used to study the cytotoxicity of and microalgae extracts, and a synergy matrix effect was used to study the combined effect of the extracts. Isobologram analysis and the highest single agent synergy model were applied to study and validate the synergy between the extracts from and microalgae. Ethanol-based extraction and supercritical water extract significantly inhibited the growth of various mammalian cancer cells compared to aqueous extracts. Osteosarcoma cells were more susceptible to the supercritical extracts of and chlorophyll-free and sugar-free ethanol extracts of microalgae. A combination of ethanol-based extract and chlorophyll-free microalgae extract resulted in a synergistic interaction with various tested cancer cells. This study provides experimental evidence supporting the potential therapeutic application of and microalgae extracts with a synergistic effect to inhibit the growth of various mammalian cancer cells. Additional in vivo studies are required to fully explore possible therapeutic applications of these unique mixtures to be used in treating cancers.

摘要

桦褐孔菌（）含有生物活性代谢物，已被用于治疗各种疾病，包括癌症。同样，海洋微藻被认为是一种具有抗癌和抗氧化特性的可持续食品补充剂。本研究调查了不同提取物的细胞毒性，这些提取物分别来自桦褐孔菌和微藻，使用培养的人源和犬源癌细胞系（MCF-7、HepG2、HOS、D-17 和 DH-82）进行研究。MTS 细胞活力测定法用于研究桦褐孔菌和微藻提取物的细胞毒性，协同矩阵效应用于研究提取物的协同作用。等效应线分析和最高单药协同模型用于研究和验证桦褐孔菌和微藻提取物之间的协同作用。与水提取物相比，基于乙醇的提取和超临界水提取物显著抑制了各种哺乳动物癌细胞的生长。骨肉瘤细胞对桦褐孔菌的超临界提取物以及无叶绿素和无糖乙醇提取物的微藻更敏感。基于乙醇的桦褐孔菌提取物和无叶绿素的微藻提取物的组合与各种测试的癌细胞产生协同相互作用。这项研究提供了实验证据，支持桦褐孔菌和微藻提取物具有协同作用抑制各种哺乳动物癌细胞生长的潜在治疗应用。需要进行更多的体内研究，以充分探索这些独特混合物在治疗癌症方面的潜在治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/0237b0eaecd7/OMCL2024-7944378.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/501f432eee34/OMCL2024-7944378.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/1090253af805/OMCL2024-7944378.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/f3ebe5faee5b/OMCL2024-7944378.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/7eb3d64f4eeb/OMCL2024-7944378.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/0237b0eaecd7/OMCL2024-7944378.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/501f432eee34/OMCL2024-7944378.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/1090253af805/OMCL2024-7944378.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/f3ebe5faee5b/OMCL2024-7944378.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/7eb3d64f4eeb/OMCL2024-7944378.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49dd/10807943/0237b0eaecd7/OMCL2024-7944378.005.jpg

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