文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

通过组织特异性多祖分子数据推进人类基因组学中的公平性。

Advancing equity in human genomics through tissue-specific multi-ancestry molecular data.

机构信息

Institute of Translational Genomics, Helmholtz Munich, 85764 Neuherberg, Germany; Munich School for Data Science, Helmholtz Munich, 85764 Neuherberg, Germany; Technical University of Munich, School of Medicine, Graduate School of Experimental Medicine, 81675 Munich, Germany.

Institute of Translational Genomics, Helmholtz Munich, 85764 Neuherberg, Germany; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester M13 9PT, UK.

出版信息

Cell Genom. 2024 Feb 14;4(2):100485. doi: 10.1016/j.xgen.2023.100485. Epub 2024 Jan 24.

DOI:10.1016/j.xgen.2023.100485
PMID:38272034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10879035/
Abstract

There is a pressing need to generate molecular data from diverse tissues across global populations. These currently missing data are necessary to resolve genome-wide association study loci, identify effector genes, and move the translational genomics needle beyond European-ancestry individuals and the minority of diseases for which blood is the relevant tissue.

摘要

目前迫切需要从全球不同人群的各种组织中生成分子数据。这些缺失的数据对于解析全基因组关联研究的基因座、鉴定效应基因以及推动转化基因组学超越欧洲血统个体和少数血液相关疾病至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e424/10879035/e387b4463fec/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e424/10879035/e2f78e8eb163/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e424/10879035/e387b4463fec/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e424/10879035/e2f78e8eb163/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e424/10879035/e387b4463fec/gr2.jpg

相似文献

[1]
Advancing equity in human genomics through tissue-specific multi-ancestry molecular data.

Cell Genom. 2024-2-14

[2]
Genomic study of maternal lipid traits in early pregnancy concurs with four known adult lipid loci.

J Clin Lipidol. 2023

[3]
Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study.

Hum Reprod. 2013-3-18

[4]
Next generation disparities in human genomics: concerns and remedies.

Trends Genet. 2009-11

[5]
Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.

Elife. 2022-7-8

[6]
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

Stroke. 2015-8

[7]
Optimal strategies for learning multi-ancestry polygenic scores vary across traits.

Nat Commun. 2023-7-7

[8]
A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.

Am J Hum Genet. 2022-3-3

[9]
MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies.

Nat Genet. 2024-1

[10]
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Nat Commun. 2018-7-30

引用本文的文献

[1]
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.

medRxiv. 2025-5-7

[2]
Translational genomics of osteoarthritis in 1,962,069 individuals.

Nature. 2025-4-9

[3]
Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation.

bioRxiv. 2025-3-17

[4]
Transferability of Single- and Cross-Tissue Transcriptome Imputation Models Across Ancestry Groups.

Genet Epidemiol. 2025-1

[5]
Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis.

Am J Hum Genet. 2024-12-5

[6]
Genome-wide association testing beyond SNPs.

Nat Rev Genet. 2025-3

[7]
Multi-omics characterization of type 2 diabetes associated genetic variation.

medRxiv. 2024-7-15

本文引用的文献

[1]
Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.

Nat Commun. 2023-5-30

[2]
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.

Cell Genom. 2022-10-12

[3]
Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank.

Nat Commun. 2023-2-3

[4]
Multi-Omics Studies in Historically Excluded Populations: The Road to Equity.

Clin Pharmacol Ther. 2023-3

[5]
Prevalence and prediction of medical distrust in a diverse medical genomic research sample.

Genet Med. 2022-7

[6]
Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans.

Hum Mol Genet. 2021-7-28

[7]
The GTEx Consortium atlas of genetic regulatory effects across human tissues.

Science. 2020-9-11

[8]
Mechanisms of tissue and cell-type specificity in heritable traits and diseases.

Nat Rev Genet. 2020-1-8

[9]
Genomics of disease risk in globally diverse populations.

Nat Rev Genet. 2019-6-24

[10]
The new era of precision population health: insights for the All of Us Research Program and beyond.

J Transl Med. 2018-7-27

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索