Zhejiang Key Laboratory of Pathophysiology, NBU Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.
Department of Clinical Laboratory, The Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Eur J Med Res. 2024 Jan 29;29(1):81. doi: 10.1186/s40001-024-01653-6.
Stroke stands as the second leading cause of death worldwide. Currently, extensive research has been conducted on stroke risk factors. However, when stroke patients contend with multiple risk factors, the impact on clinical indicators remains uncertain.
This study seeks to investigate potential significant variations among distinct ranges of clinical indicators in instances where stroke patients experience multiple risk factors and various ischemic stroke subtypes.
The research encompassed 440 stroke patients admitted to the First People's Hospital of Wenling City, Zhejiang Province, China. These patients were classified based on the type and quantity of risk factors and subtypes of ischemic stroke they presented. The χ test was employed to assess the relationship between the risk of comorbid diseases and clinical indicators in stroke patients.
The results of our study have underscored a significant correlation between various comorbid risk factors in stroke patients and the patients' age (P < 0.010). Furthermore, we observed noteworthy disparities in the plasma levels of IL-2, IL-4, IL-6, IL-10, TNF-α, and INF-γ between patients devoid of risk factors and those presenting with comorbid risk factors associated with stroke. Significant differences in INF-γ were observed between the two subtypes of ischemic stroke, namely lacunar infarction and cardioembolic stroke.
Age is correlated with an elevated risk of stroke. Individuals exhibiting multiple stroke risk factors and diverse ischemic stroke subtypes commonly present with abnormal lipid levels and imbalances in Th1/Th2 cytokines. These factors significantly contribute to the onset and progression of stroke. Furthermore, inflammatory responses, particularly those induced by atherosclerosis, play a pivotal role in the genesis of stroke and exert a substantial influence on its prognosis.
中风是全球第二大致死原因。目前，大量研究集中在中风风险因素上。然而，当中风患者面临多种风险因素时，其对临床指标的影响尚不确定。
本研究旨在探讨中风患者存在多种风险因素和不同缺血性中风亚型时，不同临床指标范围之间是否存在潜在显著差异。
本研究纳入了 440 名在中国浙江省温岭市第一人民医院就诊的中风患者。根据患者存在的风险因素类型和数量以及缺血性中风亚型对患者进行分类。采用 χ 检验评估中风患者共患疾病风险与临床指标之间的关系。
本研究结果表明，中风患者的各种共患风险因素与患者年龄之间存在显著相关性（P<0.010）。此外，我们观察到无风险因素的患者与存在与中风相关的共患风险因素的患者之间，其血浆中 IL-2、IL-4、IL-6、IL-10、TNF-α 和 INF-γ 水平存在显著差异。两种缺血性中风亚型（腔隙性梗死和心源性栓塞性卒中）之间 INF-γ 存在显著差异。
年龄与中风风险增加相关。存在多种中风风险因素和不同缺血性中风亚型的个体通常表现出异常的血脂水平和 Th1/Th2 细胞因子失衡。这些因素是中风发病和进展的重要因素。此外，炎症反应，特别是动脉粥样硬化引起的炎症反应，在中风的发生中起关键作用，并对其预后有重大影响。
