Li Wenchao, Wang Chen, Zhang Yifei, Lu Yuan
Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
Small. 2024 Jul;20(28):e2310531. doi: 10.1002/smll.202310531. Epub 2024 Jan 29.
Due to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carriers for mRNA delivery due to their high delivery efficiency, few side effects, and easy modification to change their structures and functions. To achieve the desired biological effect, lipid nanocarriers must reach the designated location for effective drug delivery. Therefore, the effects of the composition of lipid nanocarriers on their key properties are briefly reviewed. In addition, the progress of smart drug delivery by changing the composition of lipid nanocarriers is summarized, and the importance of component design and structure is emphasized. Subsequently, this review summarizes the latest progress in lipid nanocarrier-based mRNA technology and provides corresponding strategies for its current challenges, putting forward valuable information for the future design of lipid nanocarriers and mRNA.
由于新型冠状病毒肺炎的爆发，信使核糖核酸（mRNA）技术引起了广泛关注。需要一种特异性、安全且高效的mRNA递送系统。脂质纳米载体因其高递送效率、低副作用以及易于修饰以改变其结构和功能，已成为mRNA递送的有吸引力的载体。为了实现预期的生物学效应，脂质纳米载体必须到达指定位置以实现有效的药物递送。因此，本文简要综述了脂质纳米载体的组成对其关键性质的影响。此外，总结了通过改变脂质纳米载体的组成实现智能药物递送的进展，并强调了组分设计和结构的重要性。随后，本综述总结了基于脂质纳米载体的mRNA技术的最新进展，并针对其当前面临的挑战提供了相应策略，为脂质纳米载体和mRNA的未来设计提供了有价值的信息。
