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咖啡果肉:从咖啡生产的副产品到一种潜在的防龋漱口水!一项研究。

Coffee pulp: From a by-product of coffee production to a potential anticariogenic mouth rinse! An study.

作者信息

Bollamma P B Keerthan, Nanjamma K K, Ponnappa K C

机构信息

Department of Conservative Dentistry and Endodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.

出版信息

J Conserv Dent Endod. 2023 Nov-Dec;26(6):693-696. doi: 10.4103/JCDE.JCDE_149_23. Epub 2023 Nov 22.

Abstract

BACKGROUND AND OBJECTIVES

Dental caries is a prevalent disease despite various efforts made toward its prevention. The drawbacks of the available preventive agents have led to the quest for a potentially more effective agent with fewer adverse effects. Coffee, a local produce of Coorg, is one such herbal alternative. This study aims to assess the potential antimicrobial activity of Robusta coffee pulp extracts on .

METHODOLOGY

A total of 39 participants were divided into three groups with 13 participants each, after obtaining ethical clearance and informed consent: Group A (negative control), sterile water; Group B (positive control), 0.2% chlorhexidine mouth rinse; and Group C, 2.5% coffee pulp extract rinse (prepared according to minimum inhibitory concentration). The saliva samples were collected from the patients in a sterile Eppendorf tube at prerinse for baseline, at 1-h postrinse, and at the end of 2 weeks. The colony count was done using image-based software analysis. The acquired data were statistically analyzed with one-way ANOVA and repeated measures ANOVA followed by Tukey's test.

RESULTS

Coffee pulp mouth rinse ( = 0.035) and positive control ( = 0.036) groups showed a statistically significant reduction in the microbial count at 2 weeks postrinse (compared to the negative control group).

CONCLUSION AND CLINICAL RELEVANCE

The coffee pulp extract-based mouth rinse is a potential anticariogenic agent that offers few advantages over chlorhexidine as no instances of staining, altered taste, or any allergic reactions were reported by the subjects.

摘要

背景与目的

尽管为预防龋齿做出了各种努力,但龋齿仍是一种普遍存在的疾病。现有预防剂的缺点促使人们寻求一种可能更有效的、副作用更少的药剂。咖啡是库格的一种本地产物,是这样一种草药替代品。本研究旨在评估罗布斯塔咖啡果肉提取物对……的潜在抗菌活性。

方法

在获得伦理批准和知情同意后,共有39名参与者被分为三组,每组13人:A组(阴性对照),无菌水;B组(阳性对照),0.2%氯己定漱口水;C组,2.5%咖啡果肉提取物漱口水(根据最低抑菌浓度制备)。在漱口前、漱口后1小时和2周结束时,从患者口中采集唾液样本,置于无菌的艾本德管中。使用基于图像的软件分析进行菌落计数。对获得的数据进行单因素方差分析和重复测量方差分析,然后进行Tukey检验。

结果

咖啡果肉漱口水组(P = 0.035)和阳性对照组(P = 0.036)在漱口后2周时微生物计数有统计学意义的降低(与阴性对照组相比)。

结论与临床意义

基于咖啡果肉提取物的漱口水是一种潜在的防龋剂,与氯己定相比具有一些优势,因为受试者未报告有染色、味觉改变或任何过敏反应的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc25/10823970/7c2f390182e7/JCDE-26-693-g001.jpg

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