Asbell P A, Kamenar T
Curr Eye Res. 1987 Jan;6(1):179-82. doi: 10.3109/02713688709020087.
Langerhans cells (LC) appear to have a role in the processing of antigens presented through cutaneous surfaces. In most species LC are found in the conjunctiva and limbal epithelium but are rarely found in the central cornea. A quantitative study of corneal LC was performed in guinea pigs and rabbits with HSV-1 keratitis. Corneal epithelial sheets were removed, stained with ATPase and counted in the peripheral, paracentral and central cornea. Results in guinea pigs showed statistically significant increases of LC on days 6, 16, 21 and 28 in the paracentral and central cornea of HSV eyes. Results in rabbits showed an increase in LC on days 9, 13 and 21 in the paracentral and central cornea of HSV eyes. No LC were found in the central cornea of control eyes. The results indicate a migration of LC to the central cornea as a result of HSV keratitis.
朗格汉斯细胞（LC）似乎在通过皮肤表面呈递的抗原处理过程中发挥作用。在大多数物种中，LC存在于结膜和角膜缘上皮，但在中央角膜中很少见。对患有单纯疱疹病毒1型（HSV - 1）角膜炎的豚鼠和兔子的角膜LC进行了定量研究。去除角膜上皮片，用ATP酶染色，并在周边、旁中央和中央角膜进行计数。豚鼠的结果显示，HSV感染眼的旁中央和中央角膜在第6、16、21和28天LC有统计学显著增加。兔子的结果显示，HSV感染眼的旁中央和中央角膜在第9、13和21天LC增加。对照眼的中央角膜未发现LC。结果表明，HSV角膜炎导致LC迁移至中央角膜。
