Department of Endocrinology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Department of Clinical Nutrition, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Front Public Health. 2024 Jan 24;12:1331954. doi: 10.3389/fpubh.2024.1331954. eCollection 2024.
This investigation sought to elucidate the correlations between alcohol intake and trajectories of fasting blood glucose (FBG) among American women in midlife.
Our analysis was rooted in the foundational data from the Study of Women's Health Across the Nation (SWAN), a comprehensive longitudinal study centered on US women during their midlife transition. We employed group-based trajectory modeling to chart the FBG trajectories spanning from 1996 to 2005. Employing logistic regression, we gauged the odds ratios (ORs) and 95% confidence intervals (CIs) to draw connections between initial alcohol consumption and FBG trajectory patterns, whilst controlling for predominant potential confounders.
Our cohort comprised 2,578 women in midlife, ranging in age from 42 to 52, each having a minimum of three subsequent FPG assessments. We discerned two distinct FBG trajectories: a low-stable pattern ( = 2,467) and a high-decreasing pattern ( = 111). Contrasted with the low-stable group, our data showcased an inverse relationship between alcohol intake and the high-decreasing FBG trajectory in the fully adjusted model 3. The most pronounced reduction was evident in the highest tertile of daily servings of alcoholic beverages (OR: 0.23, 95% CI: 0.10-0.52, < 0.001), percentage of kilocalories sourced from alcoholic beverages (OR: 0.30, 95% CI: 0.16-0.58, < 0.001), and daily caloric intake from alcoholic beverages (OR: 0.31, 95% CI: 0.16-0.62, < 0.001).
Moderate alcohol consumption may protect against high FPG trajectories in middle-aged women in a dose-response manner. Further researches are needed to investigate this causality in midlife women.
本研究旨在阐明美国中年女性的饮酒量与空腹血糖（FBG）轨迹之间的相关性。
我们的分析基于妇女健康全国研究（SWAN）的基础数据，这是一项以美国女性中年过渡期为中心的综合性纵向研究。我们采用基于群组的轨迹建模来绘制 1996 年至 2005 年的 FBG 轨迹。采用逻辑回归，我们评估了初始饮酒量与 FBG 轨迹模式之间的比值比（OR）和 95％置信区间（CI），同时控制了主要潜在混杂因素。
我们的队列包括 2578 名年龄在 42 至 52 岁之间的中年女性，每位女性至少有三次后续 FPG 评估。我们发现了两种不同的 FBG 轨迹：低稳定型（ = 2467）和高下降型（ = 111）。与低稳定组相比，在完全调整后的模型 3 中，我们的数据显示饮酒量与高下降型 FBG 轨迹之间呈反比关系。在最高 tertile 的每日饮酒量（OR：0.23，95％CI：0.10-0.52， < 0.001）、酒精来源卡路里百分比（OR：0.30，95％CI：0.16-0.58， < 0.001）和酒精来源日卡路里摄入量（OR：0.31，95％CI：0.16-0.62， < 0.001）方面，下降最为明显。
适量饮酒可能以剂量反应的方式预防中年女性的高 FPG 轨迹。需要进一步的研究来调查中年女性的这种因果关系。
