Tao Ruizhi, Lu Keqin, Zong Gangfan, Xia Yawen, Han Hongkuan, Zhao Yang, Wei Zhonghong, Lu Yin
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, China.
J Ginseng Res. 2023 Jan;47(1):9-22. doi: 10.1016/j.jgr.2022.07.002. Epub 2022 Jul 16.
As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells.
人参（Panax ginseng C. A. Meyer）作为中国和亚洲著名的草药，也被誉为“百草之王”，长期以来一直用于医药和保健领域。除了人参皂苷具有明显的生物活性外，人参多糖（GPs）还具有出色的抗肿瘤、抗氧化应激和免疫调节作用。特别是，GPs可以发挥抗肿瘤作用，是一种潜在的免疫调节剂。然而，由于GPs的结构和成分复杂多样，其具体的物理化学性质和潜在机制仍不清楚。在本文中，我们总结了影响GPs抗肿瘤活性的因素及其作用机制，包括对免疫系统的刺激、对肠道微生物群的调节以及对肿瘤细胞的直接作用。
