智力残疾成年人中癌症的患病率和发病率——一项系统评价与荟萃分析方案
Prevalence and incidence of cancer amongst adults with intellectual disability - a systematic review and meta-analysis protocol.
作者信息
McMahon Martin, Lynch Louise, Wormald Andrew, Eustace-Cook Jessica, McCarron Mary, McCallion Philip, Smith Valerie
机构信息
School of Nursing & Midwifery, The University of Dublin Trinity College, Dublin, D02 PN40, Ireland.
Trinity Centre for Ageing with Intellectual Disability (TCAID), The University of Dublin Trinity College, School of Nursing & Midwifery, Dublin, Ireland.
出版信息
HRB Open Res. 2024 Feb 2;6:51. doi: 10.12688/hrbopenres.13740.2. eCollection 2023.
BACKGROUND
People with intellectual disabilities have poorer health and die earlier than their peers without identified disabilities. This difference represents a significant inequality. Until recently, it was considered that cancer was less common in this population, mainly because they did not live long enough to develop age-related cancers. However, recent evidence has identified that people with intellectual disabilities may be at an increased risk of developing cancer but more likely to present for medical treatment at a later stage when cancer has spread. Nonetheless, the evidence is lacking and there is a need to understand the prevalence and incidence of cancer and subtypes of cancer in adults with intellectual disabilities.
METHODS
A systematic review and meta-analysis will be undertaken to investigate the prevalence and incidence of cancer and subtypes of cancer in adults with an intellectual disability. The JBI Systematic reviews of prevalence and incidence and the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to develop this protocol. Electronic databases will be searched using predefined search terms to identify relevant studies using the Condition Context Population (CoCoPop) framework. Eligible studies should be observational and have published baseline data that have estimated or presented data on the prevalence or incidence of cancer in adults with intellectual disabilities. To assess the methodological quality of studies included in this review a modified version of the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data will be used. Prevalence and incidence proportions will be analysed separately with individual study data being pooled using the DerSimonian-Laird proportion method and a random effects meta-analysis will be undertaken.
DISCUSSION
This review will advance the epidemiological evidence to identify where targeted cancer care interventions are needed to help reduce the inequalities that this population experiences.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO registration number: CRD42023423584.
背景
与未被确诊为残疾的同龄人相比，智障人士健康状况更差，寿命更短。这种差异体现了显著的不平等。直到最近，人们还认为癌症在这一人群中不太常见，主要是因为他们寿命不够长，无法患上与年龄相关的癌症。然而，最近的证据表明，智障人士患癌症的风险可能更高，但在癌症扩散到晚期时才更有可能就医。尽管如此，证据仍然不足，有必要了解智障成年人中癌症的患病率、发病率以及癌症亚型情况。
方法
将进行一项系统评价和荟萃分析，以调查智障成年人中癌症的患病率、发病率以及癌症亚型情况。遵循JBI患病率和发病率系统评价以及PRISMA-P（系统评价和荟萃分析的首选报告项目）指南来制定本方案。将使用预定义的搜索词在电子数据库中进行检索，以使用疾病背景人群（CoCoPop）框架识别相关研究。符合条件的研究应为观察性研究，并已发表基线数据，这些数据估计或呈现了智障成年人中癌症的患病率或发病率数据。为评估纳入本评价的研究的方法学质量，将使用JBI报告患病率数据研究的批判性评价清单的修改版。患病率和发病率比例将分别进行分析，使用DerSimonian-Laird比例法汇总个体研究数据，并进行随机效应荟萃分析。
讨论
本评价将推进流行病学证据，以确定需要在哪些方面进行有针对性的癌症护理干预，以帮助减少这一人群所经历的不平等现象。
系统评价注册
PROSPERO注册号：CRD42023423584。
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