Department of BioNano Technology, Gachon University, Gyeonggi 13120, Republic of Korea.
Precision Medicine Research Institute, Samsung Medical Center, Seoul 08826, Republic of Korea; Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul 08826, Republic of Korea.
Adv Drug Deliv Rev. 2024 Apr;207:115202. doi: 10.1016/j.addr.2024.115202. Epub 2024 Feb 8.
The symbiotic interplay of organoid technology and advanced imaging strategies yields innovative breakthroughs in research and clinical applications. Organoids, intricate three-dimensional cell cultures derived from pluripotent or adult stem/progenitor cells, have emerged as potent tools for in vitro modeling, reflecting in vivo organs and advancing our grasp of tissue physiology and disease. Concurrently, advanced imaging technologies such as confocal, light-sheet, and two-photon microscopy ignite fresh explorations, uncovering rich organoid information. Combined with advanced imaging technologies and the power of artificial intelligence, organoids provide new insights that bridge experimental models and real-world clinical scenarios. This review explores exemplary research that embodies this technological synergy and how organoids reshape personalized medicine and therapeutics.
类器官技术与先进成像策略的共生相互作用为研究和临床应用带来了创新性突破。类器官是从多能性或成体干细胞衍生而来的复杂三维细胞培养物，已成为体外建模的有力工具，反映了体内器官的情况，并增进了我们对组织生理学和疾病的理解。与此同时，先进的成像技术，如共聚焦、光片和双光子显微镜，激发了新的探索，揭示了丰富的类器官信息。结合先进的成像技术和人工智能的力量，类器官提供了新的见解，弥合了实验模型和真实临床场景之间的差距。这篇综述探讨了体现这种技术协同作用的范例研究，以及类器官如何重塑个性化医疗和治疗。
