Zawadzki Tomasz, Sitek Aneta, Antoszewski Bogusław, Kasielska-Trojan Anna
Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, 90-153 Lodz, Poland.
Department of Anthropology, University of Lodz, 90-237 Lodz, Poland.
J Clin Med. 2024 Jan 25;13(3):691. doi: 10.3390/jcm13030691.
: Platelet-rich plasma (PRP) has been shown to support wound healing and tissue regeneration due to its high concentration of growth factors and cytokines. This study aims to investigate the effect of intraoperative PRP injections on the final appearance of vertical scars after breast reduction, as well as to identify potential predictors of a scar's aesthetic assessment using spectrophotometric parameters. : In this prospective, randomized trial, 82 scars from 41 women who underwent bilateral breast reduction with an inverted T pattern were analyzed. PRP or a placebo substance (0.9% sodium chloride solution) was injected intraoperatively into the edges of vertical wounds. Spectrophotometric measurements of scar pigmentation were performed 3 and 6 months after surgery; additionally, two independent observers evaluated the aesthetic appearance of scars based on photographs. : The results showed that the use of intraoperative PRP injections did not significantly influence the final appearance of vertical scars after breast reduction. : We indicated spectrophotometric variables (b) in the early stages of wound healing (after 3 months) that can be predictors of the final scar's aesthetic outcome. This can be helpful in detecting scars that may need additional interventions to optimize the healing process.
富含血小板血浆（PRP）因其高浓度的生长因子和细胞因子已被证明有助于伤口愈合和组织再生。本研究旨在探讨术中注射PRP对乳房缩小术后垂直瘢痕最终外观的影响，并使用分光光度参数确定瘢痕美学评估的潜在预测指标。
在这项前瞻性随机试验中，分析了41例行双侧倒T形乳房缩小术的女性的82条瘢痕。术中将PRP或一种安慰剂物质（0.9%氯化钠溶液）注射到垂直伤口边缘。术后3个月和6个月对瘢痕色素沉着进行分光光度测量；此外，两名独立观察者根据照片评估瘢痕的美学外观。
结果表明，术中注射PRP对乳房缩小术后垂直瘢痕的最终外观没有显著影响。
我们指出了伤口愈合早期（3个月后）的分光光度变量（b），其可作为最终瘢痕美学结果的预测指标。这有助于检测可能需要额外干预以优化愈合过程的瘢痕。
