• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

冷冻麻醉和甜味溶液对减轻7至10岁儿科患者注射疼痛的效果:一项随机对照试验。

Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7-10 years: a randomized controlled trial.

作者信息

Davangere Padmanabh Shital Kiran, Gangurde Vishakha Bhausaheb, Jhamb Vikram, Gori Nasrin

机构信息

Department of Pediatric and Preventive Dentistry, College of Dental Sciences, At. Amargadh, Tal. Sihor, Dist. Bhavnagar, Gujarat, India.

出版信息

J Dent Anesth Pain Med. 2024 Feb;24(1):37-45. doi: 10.17245/jdapm.2024.24.1.37. Epub 2024 Feb 1.

DOI:10.17245/jdapm.2024.24.1.37
PMID:38362255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10864708/
Abstract

BACKGROUND

The delivery of profound local anesthetics helps children receive successful treatment by reducing fear, anxiety, and discomfort during dental procedures. Local anesthetic injections are the most anticipated stimuli in dental surgery. Children's perceptions of pain can be altered by applying cryotherapy to precool the oral mucosa or by diverting their minds through taste distractions before administering local anesthetic injections. This study aimed to evaluate the efficacy of cryoanesthesia and xylitol sweet-tasting solution at the injection site in 7-10-year-old children.

METHODS

A total of 42 participants, aged 7-10 years, who underwent dental treatment requiring local anesthesia, were enrolled in the study. The children were randomly divided into three groups. In group I, sterile water was held in the mouth for 2 minutes before anesthetic administration, similar to group II, and in group III, a xylitol sweet-tasting solution was used for 2 minutes before needle insertion. The analysis of pain perception was carried out based on the Visual Analog Scale (VAS) and the Sound, Eyes, and Motor (SEM) scale. For VAS analysis, a one-way analysis of variance (ANOVA) was performed for intergroup comparison, and a post hoc Tukey test was performed for subgroup analysis. For the categorical SEM scale, the Kruskal-Wallis test followed by the post hoc test was performed for intergroup comparison. Where a P value of <0.05 was considered statistically significant at 95% confidence intervals.

RESULTS

Cryoanesthesia significantly reduced pain scores on VAS (4.21 ± 1.42) when compared to those on VAS with xylitol sweet-tasting solution (5.50 ± 1.40) and that with sterile water (6.14 ± 2.47). Intergroup comparison of the VAS scores among the three groups was performed using one-way ANOVA, which demonstrated statistically significant differences (P value <0.026) on the VAS scale. Intergroup comparison of the SEM scale was performed using the Kruskal-Wallis test, followed by post hoc comparison, which exhibited statistically significant differences (P < 0.007) among the three groups for the SEM scale.

CONCLUSION

Cryoanesthesia demonstrated higher efficacy in reducing injection pain than that exhibited by the xylitol sweet-tasting solution.

摘要

背景

深度局部麻醉剂的使用有助于儿童在牙科治疗过程中减少恐惧、焦虑和不适,从而获得成功的治疗。局部麻醉注射是牙科手术中最令人担忧的刺激因素。在进行局部麻醉注射前,通过应用冷冻疗法对口腔黏膜进行预冷或通过味觉分散来转移儿童的注意力,可以改变他们对疼痛的感知。本研究旨在评估冷冻麻醉和木糖醇甜味溶液在7至10岁儿童注射部位的效果。

方法

共有42名年龄在7至10岁、需要进行局部麻醉的牙科治疗参与者纳入本研究。这些儿童被随机分为三组。在第一组中,与第二组一样,在给予麻醉剂前将无菌水含在口中2分钟,在第三组中,在插入针头前使用木糖醇甜味溶液2分钟。基于视觉模拟量表(VAS)和声音、眼睛及动作(SEM)量表进行疼痛感知分析。对于VAS分析,进行组间比较的单因素方差分析(ANOVA),并进行事后Tukey检验进行亚组分析。对于分类的SEM量表,进行组间比较的Kruskal-Wallis检验及事后检验。在95%置信区间,P值<0.05被认为具有统计学意义。

结果

与使用木糖醇甜味溶液(5.50±1.40)和无菌水(6.14±2.47)时的VAS评分相比,冷冻麻醉显著降低了VAS上的疼痛评分(4.21±1.42)。使用单因素方差分析对三组之间的VAS评分进行组间比较,结果显示在VAS量表上存在统计学显著差异(P值<0.026)。使用Kruskal-Wallis检验进行SEM量表的组间比较,随后进行事后比较,结果显示在SEM量表上三组之间存在统计学显著差异(P<0.007)。

结论

冷冻麻醉在减轻注射疼痛方面比木糖醇甜味溶液显示出更高的疗效。

相似文献

1
Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7-10 years: a randomized controlled trial.冷冻麻醉和甜味溶液对减轻7至10岁儿科患者注射疼痛的效果:一项随机对照试验。
J Dent Anesth Pain Med. 2024 Feb;24(1):37-45. doi: 10.17245/jdapm.2024.24.1.37. Epub 2024 Feb 1.
2
Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial.冷冻疗法应用于口内注射时对疼痛感知的疗效:一项随机对照试验。
Int J Clin Pediatr Dent. 2021 Sep-Oct;14(5):616-620. doi: 10.5005/jp-journals-10005-2032.
3
The efficacy of administrating a sweet-tasting solution for reducing the pain related to dental injections in children: A randomized controlled trial.给予甜味溶液以减轻儿童牙科注射相关疼痛的效果:一项随机对照试验。
Int J Paediatr Dent. 2021 Mar;31(2):184-190. doi: 10.1111/ipd.12697. Epub 2020 Aug 25.
4
Efficacy of sucrose application in minimizing pain perception related to dental injection in children aged 3 to 9 years: a randomized control trial.蔗糖用于减轻3至9岁儿童牙科注射相关疼痛感知的疗效:一项随机对照试验。
J Dent Anesth Pain Med. 2024 Apr;24(2):109-117. doi: 10.17245/jdapm.2024.24.2.109. Epub 2024 Mar 28.
5
Effectiveness of precooling the injection site using tetrafluorethane on pain perception in children.使用四氟乙烷预冷注射部位对儿童疼痛感知的有效性。
J Indian Soc Pedod Prev Dent. 2018 Jul-Sep;36(3):296-300. doi: 10.4103/JISPPD.JISPPD_222_17.
6
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.药物及联合干预措施在减轻儿童常规免疫接种时注射疼痛方面的有效性和耐受性:系统评价与荟萃分析
Clin Ther. 2009;31 Suppl 2:S104-51. doi: 10.1016/j.clinthera.2009.08.001.
7
Evaluation of the effectiveness of sucrose versus xylitol application in minimizing pain related to dental injection in 5-7-year-old children - A randomized controlled pilot study.评估蔗糖与木糖醇用于减轻 5-7 岁儿童牙科注射疼痛的效果 - 一项随机对照初步研究。
J Indian Soc Pedod Prev Dent. 2023 Jul-Sep;41(3):216-221. doi: 10.4103/jisppd.jisppd_250_23.
8
Effectiveness of cryotherapy, sucrose solution and a combination therapy for pain control during local anesthesia in children: a split mouth study.冷冻疗法、蔗糖溶液及联合疗法在儿童局部麻醉期间控制疼痛的有效性:一项双侧对照研究。
J Clin Pediatr Dent. 2022 Nov;46(6):1-5. doi: 10.22514/jocpd.2022.018. Epub 2022 Nov 1.
9
Effectiveness of Pre-administered Natural Sweet-tasting Solution for Decreasing Pain Associated with Dental Injections in Children: A Split-mouth Randomized Controlled Trial.预给天然甜味溶液减少儿童牙科注射疼痛的效果:一项分口随机对照试验。
J Contemp Dent Pract. 2021 Dec 1;22(12):1434-1437.
10
Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years.用于减轻1至16岁儿童与针头相关的操作疼痛的甜味溶液。
Cochrane Database Syst Rev. 2015 May 5;2015(5):CD008408. doi: 10.1002/14651858.CD008408.pub3.

引用本文的文献

1
The efficacy of sweet solutions on dental injection related pain: a systematic review of randomized controlled trials.甜味溶液对牙科注射相关疼痛的疗效:随机对照试验的系统评价
J Dent Anesth Pain Med. 2025 Apr;25(2):83-96. doi: 10.17245/jdapm.2025.25.2.83. Epub 2025 Mar 27.
2
Topical anesthetics methods used to reduce needle pain/discomfort prior to local anesthesia in children and adolescents: a scoping review.用于减轻儿童和青少年局部麻醉前针刺痛/不适的局部麻醉方法:一项范围综述
Evid Based Dent. 2025 Mar;26(1):65. doi: 10.1038/s41432-025-01106-x. Epub 2025 Jan 24.
3
Efficacy of local anesthesia with cryotherapy on teeth with molar incisal hypomineralization: a randomized control trial.

本文引用的文献

1
Sucrose solution for alleviating needle pain during inferior alveolar nerve block in children aged 7-10 years: a randomized clinical trial.用于减轻7至10岁儿童下牙槽神经阻滞时注射疼痛的蔗糖溶液:一项随机临床试验。
J Dent Anesth Pain Med. 2023 Oct;23(5):273-280. doi: 10.17245/jdapm.2023.23.5.273. Epub 2023 Sep 27.
2
Effectiveness of Pre-administered Natural Sweet-tasting Solution for Decreasing Pain Associated with Dental Injections in Children: A Split-mouth Randomized Controlled Trial.预给天然甜味溶液减少儿童牙科注射疼痛的效果:一项分口随机对照试验。
J Contemp Dent Pract. 2021 Dec 1;22(12):1434-1437.
3
Efficacy of Cryotherapy Application on the Pain Perception during Intraoral Injection: A Randomized Controlled Trial.
冷冻疗法局部麻醉对磨牙切端矿化不全牙齿的疗效:一项随机对照试验。
J Dent Anesth Pain Med. 2024 Dec;24(6):385-393. doi: 10.17245/jdapm.2024.24.6.385. Epub 2024 Nov 26.
4
Efficacy of sucrose application in minimizing pain perception related to dental injection in children aged 3 to 9 years: a randomized control trial.蔗糖用于减轻3至9岁儿童牙科注射相关疼痛感知的疗效:一项随机对照试验。
J Dent Anesth Pain Med. 2024 Apr;24(2):109-117. doi: 10.17245/jdapm.2024.24.2.109. Epub 2024 Mar 28.
冷冻疗法应用于口内注射时对疼痛感知的疗效:一项随机对照试验。
Int J Clin Pediatr Dent. 2021 Sep-Oct;14(5):616-620. doi: 10.5005/jp-journals-10005-2032.
4
The efficacy of administrating a sweet-tasting solution for reducing the pain related to dental injections in children: A randomized controlled trial.给予甜味溶液以减轻儿童牙科注射相关疼痛的效果:一项随机对照试验。
Int J Paediatr Dent. 2021 Mar;31(2):184-190. doi: 10.1111/ipd.12697. Epub 2020 Aug 25.
5
Pain perception and efficacy of local analgesia using 2% lignocaine, buffered lignocaine, and 4% articaine in pediatric dental procedures.在儿童牙科手术中使用2%利多卡因、缓冲利多卡因和4%阿替卡因的疼痛感知及局部镇痛效果
J Dent Anesth Pain Med. 2019 Apr;19(2):101-109. doi: 10.17245/jdapm.2019.19.2.101. Epub 2019 Apr 30.
6
Effectiveness of precooling the injection site using tetrafluorethane on pain perception in children.使用四氟乙烷预冷注射部位对儿童疼痛感知的有效性。
J Indian Soc Pedod Prev Dent. 2018 Jul-Sep;36(3):296-300. doi: 10.4103/JISPPD.JISPPD_222_17.
7
Sucrose for analgesia in newborn infants undergoing painful procedures.蔗糖用于接受疼痛性操作的新生儿镇痛。
Cochrane Database Syst Rev. 2016 Jul 16;7(7):CD001069. doi: 10.1002/14651858.CD001069.pub5.
8
Pain management during needle insertion with low level laser.使用低强度激光进行针刺时的疼痛管理。
Eur J Paediatr Dent. 2016 Jun;17(2):151-4.
9
Xylitol-containing products for preventing dental caries in children and adults.用于预防儿童和成人龋齿的含木糖醇产品。
Cochrane Database Syst Rev. 2015 Mar 26;2015(3):CD010743. doi: 10.1002/14651858.CD010743.pub2.
10
[Effects of different types and concentration of oral sweet solution on reducing neonatal pain during heel lance procedures].[不同类型及浓度的口服甜味溶液对减轻足跟采血过程中新生儿疼痛的影响]
Zhonghua Er Ke Za Zhi. 2013 Sep;51(9):654-8.