Altuhafy Maryam, Ahuja Tanvi Kaur, Khan Junad
Department of Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester, NY, USA.
J Dent Anesth Pain Med. 2025 Apr;25(2):83-96. doi: 10.17245/jdapm.2025.25.2.83. Epub 2025 Mar 27.
Oral flavored solutions are effective for pain management. The intraoral application of sweet solutions at the injection site or on the tongue before local anesthetic administration leads to lower self-perceived pain than any other intervention. This systematic review aimed to evaluate the effect of sweet taste on injection pain in patients undergoing dental procedures. This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42024571962 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). An initial electronic search without a time limit up to September 2024 revealed 1,087 studies from indexed databases (PubMed, Scopus, Embase, Cochrane, and Web of Science). The Cochrane Bias Assessment Tool was used to evaluate the risk of bias. After eliminating duplicate and automated records, 103 studies were screened for inclusion. After reviewing the titles and abstracts and assessing the eligibility of the studies, three were excluded and eight RCTs were considered appropriate for inclusion and analysis. This review highlights that all the included studies reported significantly reduced pain perception after sweet solutions, regardless of the specific type or concentration.
口服调味溶液对疼痛管理有效。在局部麻醉给药前，在注射部位或舌头上口腔内应用甜味溶液，与任何其他干预措施相比，能降低自我感知的疼痛。本系统评价旨在评估甜味对接受牙科手术患者注射疼痛的影响。本系统评价已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号为CRD42024571962，并遵循系统评价和Meta分析的首选报告项目（PRISMA）。截至2024年9月的初步无时间限制电子检索，从索引数据库（PubMed、Scopus、Embase、Cochrane和Web of Science）中检索到1087项研究。使用Cochrane偏倚评估工具评估偏倚风险。在消除重复和自动记录后，筛选了103项研究以纳入。在审查标题和摘要并评估研究的 eligibility后，排除了3项研究，8项随机对照试验被认为适合纳入和分析。本综述强调，所有纳入的研究均报告甜味溶液后疼痛感知显著降低，无论具体类型或浓度如何。 （注：原文中“eligibility”可能有误，推测应为“eligibility”，意为“合格性”“适宜性” ，这里按推测翻译。）
