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一种用于在微观医学图像中检测红细胞以进行各种血液结构分类的智能神经网络模型。

An intelligent neural network model to detect red blood cells for various blood structure classification in microscopic medical images.

作者信息

Khan Riaz Ullah, Almakdi Sultan, Alshehri Mohammed, Haq Amin Ul, Ullah Aman, Kumar Rajesh

机构信息

Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, China.

Department of Computer Science, College of Computer Science and Information systems, Najran University, Najran 55461, Saudi Arabia.

出版信息

Heliyon. 2024 Feb 13;10(4):e26149. doi: 10.1016/j.heliyon.2024.e26149. eCollection 2024 Feb 29.

DOI:10.1016/j.heliyon.2024.e26149
PMID:38384569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10879026/
Abstract

Biomedical image analysis plays a crucial role in enabling high-performing imaging and various clinical applications. For the proper diagnosis of blood diseases related to red blood cells, red blood cells must be accurately identified and categorized. Manual analysis is time-consuming and prone to mistakes. Analyzing multi-label samples, which contain clusters of cells, is challenging due to difficulties in separating individual cells, such as touching or overlapping cells. High-performance biomedical imaging and several medical applications are made possible by advanced biosensors. We develop an intelligent neural network model that can automatically identify and categorize red blood cells from microscopic medical images using region-based convolutional neural networks (RCNN) and cutting-edge biosensors. Our model successfully navigates obstacles like touching or overlapping cells and accurately recognizes various blood structures. Additionally, we utilized data augmentation as a pre-processing method on microscopic images to enhance the model's computational efficiency and expand the sample size. To refine the data and eliminate noise from the dataset, we utilized the Radial Gradient Index filtering algorithm for imaging data equalization. We exhibit improved detection accuracy and a reduced model loss rate when using medical imagery datasets to apply our proposed model in comparison to existing ResNet and GoogleNet models. Our model precisely detected red blood cells in a collection of medical images with 99% training accuracy and 91.21% testing accuracy. Our proposed model outperformed earlier models like ResNet-50 and GoogleNet by 10-15%. Our results demonstrated that Artificial intelligence (AI)-assisted automated red blood cell detection has the potential to revolutionize and speed up blood cell analysis, minimizing human error and enabling early illness diagnosis.

摘要

生物医学图像分析在实现高性能成像和各种临床应用中起着至关重要的作用。为了正确诊断与红细胞相关的血液疾病,必须准确识别和分类红细胞。手动分析既耗时又容易出错。分析包含细胞簇的多标签样本具有挑战性,因为难以分离单个细胞,例如相互接触或重叠的细胞。先进的生物传感器使高性能生物医学成像和一些医学应用成为可能。我们开发了一种智能神经网络模型,该模型可以使用基于区域的卷积神经网络(RCNN)和前沿生物传感器从微观医学图像中自动识别和分类红细胞。我们的模型成功克服了诸如细胞相互接触或重叠等障碍,并准确识别了各种血液结构。此外,我们将数据增强作为微观图像的一种预处理方法,以提高模型的计算效率并扩大样本量。为了优化数据并消除数据集中的噪声,我们使用径向梯度指数滤波算法进行成像数据均衡。与现有的ResNet和GoogleNet模型相比,当使用医学图像数据集应用我们提出的模型时,我们展示了更高的检测准确率和更低的模型损失率。我们的模型在一组医学图像中精确检测红细胞,训练准确率为99%,测试准确率为91.21%。我们提出的模型比ResNet - 50和GoogleNet等早期模型性能高出10 - 15%。我们的结果表明,人工智能(AI)辅助的自动红细胞检测有可能彻底改变并加速血细胞分析,最大限度地减少人为错误并实现疾病早期诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a44/10879026/154a2250290a/gr008.jpg
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