Clinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Medicine (Baltimore). 2024 Feb 23;103(8):e37295. doi: 10.1097/MD.0000000000037295.
This study aimed to identify the clinical features of gastroesophageal reflux disease (GERD) in primary clinics and the effectiveness and safety of herbal medicine (HM). Thirty-five patients with gastroesophageal-reflux symptom who visited the 16 Korean medicine (KM) primary clinics from June 2022 to October 2022 were included in the study. We retrospectively analyzed the charts of 35 patients and collected clinical characteristics, HM, and outcome variables such as the numerical rating scale, gastroesophageal reflux disease questionnaire, frequency scale for symptoms of gastroesophageal reflux disease, Euro-Quality Of Life-5 Dimension, and adverse events. Of the 35 patients, 12 (34.3%) were men, and the average age of all patients was 47.0 ± 14.3 years. HM was prescribed for all 35 patients; Pinelliae Tuber (n = 31, 88.57%), Zingiberis Rhizoma Recens (n = 30, 85.71%), and Poria Sclerotium (n = 28, 80%) were the most prescribed herbs. All scores including numerical rating scale, frequency scale for symptoms of gastroesophageal reflux disease, gastroesophageal reflux disease questionnaire, and Euro-Quality Of Life-5 Dimension after 30 and 60 days from baselines showed significant improvement, and there were only a few adverse events. This study supports the effectiveness and safety of HM in reducing GERD symptoms in primary Korean medicine clinics. The most frequently used herbs may play significant roles in GERD symptom management.
本研究旨在确定初级诊所中胃食管反流病（GERD）的临床特征，以及草药（HM）的有效性和安全性。2022 年 6 月至 2022 年 10 月期间，共有 35 名有胃食管反流症状的患者到 16 家韩国医学（KM）初级诊所就诊，我们对这 35 名患者的病历进行了回顾性分析，收集了临床特征、HM 以及数值评定量表、胃食管反流病问卷、胃食管反流症状频率量表、欧洲生活质量-5 维度和不良事件等结局变量。35 名患者中，12 名（34.3%）为男性，所有患者的平均年龄为 47.0±14.3 岁。所有 35 名患者均开具了 HM，处方最多的草药分别为半夏（n=31，88.57%）、生姜（n=30，85.71%）和茯苓（n=28，80%）。与基线相比，数值评定量表、胃食管反流症状频率量表、胃食管反流病问卷和欧洲生活质量-5 维度的所有评分在 30 天和 60 天后均显示出显著改善，且仅有少数不良事件发生。本研究支持 HM 在降低初级韩国医学诊所 GERD 症状方面的有效性和安全性。最常使用的草药可能在 GERD 症状管理中发挥重要作用。
