Rosu Luminioara M, Prodan-Bărbulescu Cătălin, Maghiari Anca Laura, Bernad Elena S, Bernad Robert L, Iacob Roxana, Stoicescu Emil Robert, Borozan Florina, Ghenciu Laura Andreea
Department of Anatomy and Embryology, Victor Babeș University of Medicine and Pharmacy, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Department of Obstetrics and Gynecology, Victor Babeș University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Diagnostics (Basel). 2024 Feb 8;14(4):369. doi: 10.3390/diagnostics14040369.
Diabetes mellitus during pregnancy and gestational diabetes are major concerns worldwide. These conditions may lead to the development of severe diabetic retinopathy during pregnancy or worsen pre-existing cases. Gestational diabetes also increases the risk of diabetes for both the mother and the fetus in the future. Understanding the prevalence, evaluating risk factors contributing to pathogenesis, and identifying treatment challenges related to diabetic retinopathy in expectant mothers are all of utmost importance. Pregnancy-related physiological changes, including those in metabolism, blood flow, immunity, and hormones, can contribute to the development or worsening of diabetic retinopathy. If left untreated, this condition may eventually result in irreversible vision loss. Treatment options such as laser therapy, intravitreal anti-vascular endothelial growth factor drugs, and intravitreal steroids pose challenges in managing these patients without endangering the developing baby and mother. This narrative review describes the management of diabetic retinopathy during pregnancy, highlights its risk factors, pathophysiology, and diagnostic methods, and offers recommendations based on findings from previous literature.
妊娠期糖尿病和妊娠糖尿病是全球主要关注的问题。这些情况可能导致孕期发生严重的糖尿病视网膜病变,或使已有的病例恶化。妊娠糖尿病还会增加母亲和胎儿未来患糖尿病的风险。了解患病率、评估导致发病机制的危险因素以及确定与孕妇糖尿病视网膜病变相关的治疗挑战至关重要。与妊娠相关的生理变化,包括代谢、血流、免疫和激素方面的变化,都可能导致糖尿病视网膜病变的发生或恶化。如果不进行治疗,这种情况最终可能导致不可逆转的视力丧失。激光治疗、玻璃体内抗血管内皮生长因子药物和玻璃体内类固醇等治疗方法,在不危及发育中的胎儿和母亲的情况下管理这些患者面临挑战。这篇叙述性综述描述了孕期糖尿病视网膜病变的管理,强调了其危险因素、病理生理学和诊断方法,并根据以往文献的研究结果提供了建议。