Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Pharmacol. 2022 Aug 5;928:175069. doi: 10.1016/j.ejphar.2022.175069. Epub 2022 Jun 1.
Although several studies have indicated that consumption of probiotics is effective in the treatment of obesity, the results in this regard have yielded controversial findings. The current umbrella meta-analysis was performed to evaluate the effects of probiotics supplementation on obesity indices in adults. Scopus, PubMed, Web of Science, Embase and Google Scholar were searched for relevant studies published till November 2021. Meta-analysis was conducted using the random-effects model. Sensitivity and subgroup analyses were performed. In total, 29 meta-analyses with 14,366 participants, including 112, 78, and 38 unique trials for body mass index (BMI), body weight (BW), and waist circumference (WC), were included in the study, respectively. The findings demonstrated that the probiotics supplementation was significantly effective on decreasing of BMI (ES = -0.21; 95% CI: -0.30, -0.13, p < 0.001; I = 83.0%, p < 0.001), BW (ES = -0.38, 95% CI: -0.60, -0.16; p < 0.001; I = 81.8%, p < 0.001), and WC (ES = -0.60; 95% CI: -0.89, -0.31; p < 0.001; I = 89.1%, p < 0.001). Greater effects on BW were observed when intervention duration was >8 weeks and on obese individuals. BMI was also greatly modified in participants with metabolic syndrome and when intervention duration lasted for ≥12 weeks. The methodological quality (AMSTAR2) was moderate in 83%, low in 10%, and critically low in 7% of included studies. The current umbrella meta-analysis indicated that supplementation of probiotics in adults led to a meaningful reduction in BW, BMI, and WC. Therefore, our findings strongly recommend supplementation with probiotics as a potent intervention in the management of obesity.
尽管有几项研究表明，益生菌的摄入在治疗肥胖症方面是有效的，但这方面的结果却产生了有争议的发现。目前的伞式荟萃分析是为了评估益生菌补充剂对成年人肥胖指数的影响。对截至 2021 年 11 月发表的相关研究，使用 Scopus、PubMed、Web of Science、Embase 和 Google Scholar 进行了检索。使用随机效应模型进行荟萃分析。进行了敏感性和亚组分析。共有 29 项荟萃分析，涉及 14366 名参与者，其中分别有 112、78 和 38 项独特的试验用于体重指数 (BMI)、体重 (BW) 和腰围 (WC)。研究结果表明，益生菌补充剂对降低 BMI (ES = -0.21; 95%CI：-0.30，-0.13，p < 0.001; I = 83.0%，p < 0.001)、BW (ES = -0.38，95%CI：-0.60，-0.16;p < 0.001; I = 81.8%，p < 0.001) 和 WC (ES = -0.60; 95%CI：-0.89，-0.31;p < 0.001; I = 89.1%，p < 0.001) 具有显著效果。当干预持续时间 >8 周且针对肥胖个体时，BW 的效果更大。在代谢综合征患者和干预持续时间至少 12 周时，BMI 也有很大的改善。纳入研究的方法学质量（AMSTAR2）在 83%的研究中为中度，在 10%的研究中为低度，在 7%的研究中为极低度。目前的伞式荟萃分析表明，在成年人中补充益生菌可显著降低 BW、BMI 和 WC。因此，我们的研究结果强烈建议补充益生菌作为肥胖症管理的有效干预措施。
