Quantitative and Visual Analysis of Data Augmentation and Hyperparameter Optimization in Deep Learning-Based Segmentation of Low-Grade Glioma Tumors Using Grad-CAM.

This study executes a quantitative and visual investigation on the effectiveness of data augmentation and hyperparameter optimization on the accuracy of deep learning-based segmentation of LGG tumors. The study employed the MobileNetV2 and ResNet backbones with atrous convolution in DeepLabV3+ structure. The Grad-CAM tool was also used to interpret the effect of augmentation and network optimization on segmentation performance. A wide investigation was performed to optimize the network hyperparameters. In addition, the study examined 35 different models to evaluate different data augmentation techniques. The results of the study indicated that incorporating data augmentation techniques and optimization can improve the performance of segmenting brain LGG tumors up to 10%. Our extensive investigation of the data augmentation techniques indicated that enlargement of data from 90° and 225° rotated data,up to down and left to right flipping are the most effective techniques. MobilenetV2 as the backbone,"Focal Loss" as the loss function and "Adam" as the optimizer showed the superior results. The optimal model (DLG-Net) achieved an overall accuracy of 96.1% with a loss value of 0.006. Specifically, the segmentation performance for Whole Tumor (WT), Tumor Core (TC), and Enhanced Tumor (ET) reached a Dice Similarity Coefficient (DSC) of 89.4%, 70.1%, and 49.9%, respectively. Simultaneous visual and quantitative assessment of data augmentation and network optimization can lead to an optimal model with a reasonable performance in segmenting the LGG tumors.