Department of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Kavrepalanchok, Nepal.
Kathmandu University School of Medical Sciences, Dhulikhel, Kavrepalanchok, Nepal.
JNMA J Nepal Med Assoc. 2024 Jan 2;62(269):5-8. doi: 10.31729/jnma.8393.
Helicobacter pylori is a gram-negative gut bacterium associated with dyspepsia, peptic ulcer disease, and gastric cancer, whose prevalence is still common in developing countries. Upper gastrointestinal endoscopy is the gold standard, first-line investigation for evaluating gastrointestinal disorders. The aim of the study was to find out the prevalence of Helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy in a tertiary care centre.
A descriptive cross-sectional study was conducted in a tertiary health care centre among the patients undergoing upper gastrointestinal endoscopy from 5 January 2020 to 5 January 2023 after obtaining ethical approval from the Institutional Review Committee. Convenience sampling method was used. The point estimate was calculated at a 99% Confidence Interval.
Among 1,975 patients, Helicobacter pylori infection was found in 561 (28.41%) (25.79-31.03, 99% Confidence Interval). The indication for upper gastrointestinal endoscopy was mostly dyspepsia 256 (45.68%) followed by abdominal pain 205 (36.54%). The most common endoscopic finding was gastritis 445 (79.32%) followed by hiatal hernia 93 (16.58%). The commonest biopsy finding was chronic active gastritis 478 (85.20%).
The prevalence of Helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy was found to be similar to other studies done in similar settings. The persistence of H. pylori emphasizes the need of continuous research to address ever evolving H. pylori infections and resistance that are developing against available treatment modalities.
endoscopy; Helicobacter pylori; upper gastrointestinal tract.
幽门螺杆菌是一种革兰氏阴性肠道细菌，与消化不良、消化性溃疡病和胃癌有关，其在发展中国家仍然很常见。上消化道内镜检查是评估胃肠道疾病的金标准、一线检查方法。本研究旨在了解三级保健中心接受上消化道内镜检查的患者中幽门螺杆菌感染的流行情况。
在获得机构审查委员会的伦理批准后，在一家三级保健中心进行了一项描述性横断面研究，研究对象为 2020 年 1 月 5 日至 2023 年 1 月 5 日期间接受上消化道内镜检查的患者。采用方便抽样法。点估计值在 99%置信区间计算。
在 1975 名患者中，发现 561 名（28.41%）（99%置信区间：25.79-31.03）感染了幽门螺杆菌。上消化道内镜检查的主要指征是消化不良 256 例（45.68%），其次是腹痛 205 例（36.54%）。最常见的内镜发现是胃炎 445 例（79.32%），其次是食管裂孔疝 93 例（16.58%）。最常见的活检发现是慢性活动性胃炎 478 例（85.20%）。
在接受上消化道内镜检查的患者中，幽门螺杆菌感染的流行率与在类似环境中进行的其他研究相似。幽门螺杆菌的持续存在强调需要不断研究，以解决不断演变的幽门螺杆菌感染和对现有治疗方法产生的耐药性。
内镜检查；幽门螺杆菌；上消化道。
