Department of Nursing, Federal University os Paraná.
Occupational Health Unit, Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico.
Med Lav. 2024 Feb 22;115(1):e2024004. doi: 10.23749/mdl.v115i1.15066.
Sinonasal cancers (SNC) are rare cancers with a high proportion attributable to occupational carcinogens. This study aims to describe the sociodemographic, clinical, and occupational characteristics of subjects with SNC in Brazil.
Observational study conducted with secondary data from a network of Hospital Cancer Registries. We selected epithelial/unspecified SNC records with a year of diagnosis from 2007 to 2021. We performed descriptive statistics of SNC cases and calculated crude and age-standardized rates (ASR, standard: world population) by gender and Region of residence.
We identified 2,384 cases, 1,553 (65.1%) in men and 831 (34.9%) in women. The mean age at diagnosis was 59 years for both. Most SNC (50.7% in men and 53.2% in women) originated from the maxillary sinus. Most (65.5% in men and 54.5% in women) were squamous cell carcinomas. Information on occupation was missing in the years 2019-2021. Most male SNC patients (44.8%) were employed in group 6 (Agricultural, forestry, and fishing workers), while women had been mainly (34.6%) working in groups 8 (Workers in the production of industrial goods and services, machine operators) and in group 6 (27.6%). Crude SNC incidence rates were 1.0 per million person-years in men and 0.5 in women, while ASR were 1.0 and 0.4, respectively. In both genders, the highest ASR was in Minas Gerais (men: 1.9; women: 0.7).
Establishing the profile of Brazilians with sinonasal cancer can stimulate epidemiologic research for monitoring this group of cancers with a high association with occupational exposures.
鼻窦癌（SNC）是一种罕见的癌症，其发病归因于职业性致癌物的比例较高。本研究旨在描述巴西 SNC 患者的社会人口学、临床和职业特征。
这是一项使用医院癌症登记处网络的二级数据进行的观察性研究。我们选择了 2007 年至 2021 年诊断年份的上皮/未特指 SNC 记录。我们对 SNC 病例进行了描述性统计，并按性别和居住地区计算了粗率和年龄标准化率（ASR，标准：世界人口）。
我们共确定了 2384 例病例，其中男性 1553 例（65.1%），女性 831 例（34.9%）。诊断时的平均年龄男女均为 59 岁。大多数 SNC（男性 50.7%，女性 53.2%）起源于上颌窦。大多数（男性 65.5%，女性 54.5%）为鳞状细胞癌。2019 年至 2021 年期间，职业信息缺失。大多数男性 SNC 患者（44.8%）从事第 6 组（农业、林业和渔业工人），而女性主要从事第 8 组（工业产品和服务生产工人、机器操作员）和第 6 组（27.6%）。男性 SNC 的粗发病率为每百万人年 1.0 例，女性为 0.5 例，而年龄标准化率分别为 1.0 和 0.4。在两性中，米纳斯吉拉斯州的年龄标准化率最高（男性：1.9；女性：0.7）。
确定巴西鼻窦癌患者的特征可以激发对这组与职业暴露高度相关的癌症的监测的流行病学研究。
