Rafaqat Saira, Patoulias Dimitrios, Behnoush Amir Hossein, Sharif Saima, Klisic Aleksandra
Department of Zoology, Lahore College for Women University, Lahore, Punjab, Pakistan.
Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece.
Arch Med Sci. 2024 Jan 31;20(1):138-156. doi: 10.5114/aoms/178183. eCollection 2024.
Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.
急性胰腺炎（AP）是一种常见的炎症状态，其临床病程可导致严重的局部和胰腺外器官功能障碍及衰竭。白细胞介素（ILs）是主要由巨噬细胞和淋巴细胞产生的具有生物活性的糖蛋白。根据文献记载，白细胞介素种类繁多。然而，本文总结了白细胞介素在急性胰腺炎中的作用，如白细胞介素-1、白细胞介素-2、白细胞介素-3、白细胞介素-4、白细胞介素-5、白细胞介素-6、白细胞介素-7、白细胞介素-8、白细胞介素-9、白细胞介素-10、白细胞介素-11、白细胞介素-12、白细胞介素-13、白细胞介素-14、白细胞介素-15、白细胞介素-16、白细胞介素-17、白细胞介素-18、白细胞介素-19和白细胞介素-20。调节白细胞介素活性以减轻炎症并改善该病患者预后的方法正在研究中。可能会研发针对特定白细胞介素的药物来减轻急性胰腺炎的影响。
