通过微生物游离DNA的下一代测序检测侵袭性感染
Detection of invasive infections with next-generation sequencing of microbial cell-free DNA.
作者信息
Centeno Fernando H, Hamdi Ahmed M, Lasco Todd M, Al Mohajer Mayar
机构信息
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Baylor St. Luke's Medical Center, Houston, TX, USA.
出版信息
Antimicrob Steward Healthc Epidemiol. 2024 Feb 12;4(1):e20. doi: 10.1017/ash.2024.16. eCollection 2024.
Abstract
We report 9 patients with invasive infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prompt diagnosis impacted antibiotic management in all 9 patients.
摘要
我们报告了9例侵袭性感染患者，其中包括5例心内膜炎患者，这些患者通过微生物游离DNA下一代测序和血清学研究得以确诊。通过血浆游离循环DNA二代测序进行诊断，使得8例患者能够更快地获得临床和实验室诊断结果。及时诊断对所有9例患者的抗生素管理产生了影响。
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