Negahdary Masoud, Barros Azeredo Nathália Florência, Santos Berlane Gomes, de Oliveira Thawan Gomes, de Oliveira Lins Renato Soares, Dos Santos Lima Irlan, Angnes Lúcio
Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. 05508-000, São Paulo, Brazil.
Curr Top Med Chem. 2023;23(4):295-315. doi: 10.2174/1568026623666221014154915.
Determining the amount of medication used is essential for correctly managing treatment systems. The unauthorized use of drugs and the importance of determining the absorbed and required dose of drugs in target organs are essential factors that justify the design of new drug monitoring systems. Electrochemical sensors and biosensors based on nanomaterials have been developed for drug monitoring in the past few years. The use of nanomaterials to optimize the analyte detection process and facilitate electron transfer in electrochemical processes has enhanced intermolecular interactions and increased diagnostic sensitivity. Considering this review, in the first part, the evaluation of cancer drugs is examined, which can be used to determine the exact dose of the drug required in different stages of cancer. Accurate monitoring of cancer drugs can increase patient life expectancy, reduce side effects, and increase economic savings. In the next section, sensors and biosensors designed for antibiotics are examined. Accurate measurement of antibiotics for determining the effectiveness of the dose in controlling infections and preventing antibiotic resistance is possible with the help of these drug diagnostic platforms. In the next part, the diagnosis of different hormones is considered. Abnormal amounts (low/high) of hormones cause multiple physiological complications and various disabilities. Therefore, accurate determination of hormone levels can effectively treat hormonal changes. In the last section, other drugs, including drugs and analgesics for which the use of electrochemical diagnostic platforms can significantly help drug distribution and social health systems, are also discussed.
确定药物使用量对于正确管理治疗系统至关重要。药物的未经授权使用以及确定靶器官中药物吸收量和所需剂量的重要性,是设计新的药物监测系统的重要因素。在过去几年中,基于纳米材料的电化学传感器和生物传感器已被开发用于药物监测。使用纳米材料优化分析物检测过程并促进电化学过程中的电子转移,增强了分子间相互作用并提高了诊断灵敏度。考虑到这篇综述,在第一部分,对癌症药物进行了评估,这些药物可用于确定癌症不同阶段所需的精确药物剂量。准确监测癌症药物可以延长患者预期寿命、减少副作用并节省经济成本。在下一部分,研究了为抗生素设计的传感器和生物传感器。借助这些药物诊断平台,可以准确测量抗生素以确定剂量在控制感染和预防抗生素耐药性方面的有效性。在接下来的部分,考虑了不同激素的诊断。激素含量异常(低/高)会导致多种生理并发症和各种残疾。因此,准确测定激素水平可以有效治疗激素变化。在最后一部分,还讨论了其他药物,包括使用电化学诊断平台可显著有助于药物分配和社会卫生系统的药物和镇痛药。