Department of Stomatology, School of Dentistry, Campus de Cartuja s/n, University of Granada, Granada, Spain.
Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain.
Clin Implant Dent Relat Res. 2024 Apr;26(2):427-441. doi: 10.1111/cid.13305. Epub 2024 Feb 28.
The aims of this study were to design a novel titanium surface coated with a PVA hydrogel matrix and chitosan-based nanoparticles and to investigate the antibiotic release and its ability to inhibit microbial activity.
Two drug delivery systems were developed and mixed. Chitosan-based nanoparticles (NP) and a polyvinyl alcohol film (PVA). The size, ζ-potential, stability, adhesive properties, and encapsulation profile of NP, as well as the release kinetics of drug delivery systems and their antimicrobial ability of PVA and PVANP films, were studied on Ti surfaces. The systems were loaded with doxycycline, vancomycin, and doxepin hydrochloride.
Nanoparticles presented a ζ-potential greater than 30 mV for 45 days and the efficiency drug encapsulation was 26.88% ± 1.51% for doxycycline, 16.09% ± 10.24% for vancomycin and 17.57% ± 11.08% for doxepin. In addition, PVA films were loaded with 125 μg/mL of doxycycline, 125 μg/mL of vancomycin, and 100 μg/mL of doxepin. PVANP-doxycycline achieved the antibacterial effect at 4 h while PVA-doxycycline maintained its effect at 24 h.
本研究旨在设计一种新型钛表面涂层，该涂层由聚乙烯醇水凝胶基质和壳聚糖基纳米颗粒组成，并研究其抗生素释放及其抑制微生物活性的能力。
开发并混合了两种药物输送系统。壳聚糖基纳米颗粒（NP）和聚乙烯醇膜（PVA）。研究了 NP 的粒径、ζ-电位、稳定性、粘附性能和包封特性，以及药物输送系统的释放动力学及其 PVA 和 PVANP 膜的抗菌能力。将这些系统加载有盐酸多西环素、万古霉素和盐酸多塞平。
纳米颗粒的 ζ-电位大于 30mV，可稳定 45 天，盐酸多西环素的药物包封效率为 26.88%±1.51%，万古霉素为 16.09%±10.24%，盐酸多塞平为 17.57%±11.08%。此外，PVA 膜加载有 125μg/mL 的盐酸多西环素、125μg/mL 的万古霉素和 100μg/mL 的盐酸多塞平。PVANP-盐酸多西环素在 4 小时达到抗菌效果，而 PVA-盐酸多西环素在 24 小时仍保持其效果。
