Yang Lian, Chen Yukun, Liu Kaile, Chen Yuanyuan, Zhang Yu, Zhang Zhanxia, Li Hegen
Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Pharmacol. 2024 Feb 14;15:1289957. doi: 10.3389/fphar.2024.1289957. eCollection 2024.
With the deepening of people's understanding of lung cancer, the research of lung cancer immunotherapy has gradually become the focus of attention. As we all know, the treatment of many diseases relies on the rich sources, complex and varied compositions and wide range of unique biological properties of natural products. Studies have shown that natural products can exert anticancer effects by inducing tumor cell death, inhibiting tumor cell proliferation, and enhancing tumor cell autophagy. More notably, natural products can adjust and strengthen the body's immune response, which includes enhancing the function of NK cells and promoting the differentiation and proliferation of T lymphocytes. In addition, these natural products may enhance their anticancer effects by affecting inhibitory factors in the immune system, hormone levels, enzymes involved in biotransformation, and modulating other factors in the tumor microenvironment. The importance of natural products in lung cancer immunotherapy should not be underestimated. However, the specific links and correlations between natural products and lung cancer immunity are not clear enough, and further studies are urgently needed to clarify the relationship between the two. In this paper, we will focus on the correlation between natural products and lung cancer immune responses, with a view to providing new research perspectives for immunotherapy of lung cancer.
随着人们对肺癌认识的不断深入，肺癌免疫治疗的研究逐渐成为关注焦点。众所周知，许多疾病的治疗依赖于天然产物丰富的来源、复杂多样的成分以及广泛独特的生物学特性。研究表明，天然产物可通过诱导肿瘤细胞死亡、抑制肿瘤细胞增殖以及增强肿瘤细胞自噬发挥抗癌作用。更值得注意的是，天然产物能够调节并强化机体的免疫反应，这包括增强自然杀伤细胞（NK细胞）的功能以及促进T淋巴细胞的分化与增殖。此外，这些天然产物可能通过影响免疫系统中的抑制因子、激素水平、参与生物转化的酶以及调节肿瘤微环境中的其他因素来增强其抗癌效果。天然产物在肺癌免疫治疗中的重要性不容小觑。然而，天然产物与肺癌免疫之间的具体联系和相关性尚不够明确，迫切需要进一步研究以阐明两者之间的关系。在本文中，我们将聚焦于天然产物与肺癌免疫反应之间的相关性，以期为肺癌免疫治疗提供新的研究视角。
