Department of Integrated Traditional and Western Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology, Zhengzhou University, Henan Province Research Center For Kidney Disease, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China.
Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin, China.
Front Immunol. 2022 Sep 2;13:972345. doi: 10.3389/fimmu.2022.972345. eCollection 2022.
Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant breakthroughs, cancer immunotherapy remains focused on several types of tumors that are sensitive to the immune system. Therefore, effective strategies to expand its indications and improve its efficacy become key factors for the further development of cancer immunotherapy. In recent decades, the anticancer activities of natural products are reported to have this effect on cancer immunotherapy. And the mechanism is largely attributed to the remodeling of the tumor immunosuppressive microenvironment. The compelling data highlight that natural products offer an alternative method option to improve immune function in the tumor microenvironment (TME). Currently, more attention is being paid to the discovery of new potential modulators of tumor immunotherapy from natural products. In this review, we describe current advances in employing natural products and natural small-molecule drugs targeting immune cells to avoid tumor immune escape, which may bring some insight for guiding tumor treatment.
癌症免疫疗法已经成为一种新的抗肿瘤治疗方法。尽管取得了重大突破，但癌症免疫疗法仍然集中在几种对免疫系统敏感的肿瘤上。因此，扩大其适应证和提高疗效的有效策略成为癌症免疫疗法进一步发展的关键因素。近几十年来，天然产物的抗癌活性被报道对癌症免疫疗法有这种作用。其机制在很大程度上归因于肿瘤免疫抑制微环境的重塑。强有力的数据突出表明，天然产物为改善肿瘤微环境（TME）中的免疫功能提供了一种替代方法。目前，人们越来越关注从天然产物中发现新的潜在肿瘤免疫治疗调节剂。在这篇综述中，我们描述了利用天然产物和针对免疫细胞的天然小分子药物来避免肿瘤免疫逃逸的最新进展，这可能为指导肿瘤治疗提供一些思路。
