Domán Marianna, Kaszab Eszter, Laczkó Levente, Bali Krisztina, Makrai László, Kovács Renátó, Majoros László, Bányai Krisztián
HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.
National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, Budapest, Hungary.
Front Vet Sci. 2024 Feb 16;11:1345877. doi: 10.3389/fvets.2024.1345877. eCollection 2024.
Stress-induced genomic changes in contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an intriguing question. Comparative genome analysis was carried out to uncover chromosomal aneuploidies and regions with loss of heterozygosity (LOH), two mechanisms that manage genome plasticity. We detected aneuploidy only in human isolates. Bird-derived isolates showed LOH in genes commonly associated with antifungal drug resistance similar to human isolates. Our study suggests that environmental fungicide usage might exert selective pressure on infecting animals, thus contributing to the spread of potentially resistant strains between different hosts.
应激诱导的基因组变化有助于该物种适应各种环境条件。动物源菌株基因组组成的变异在很大程度上尚未得到探索，驱动这些酵母进化的耐药性或其他选择压力仍然是一个有趣的问题。进行了比较基因组分析以揭示染色体非整倍性和杂合性缺失（LOH）区域，这是两种控制基因组可塑性的机制。我们仅在人类分离株中检测到非整倍性。鸟类来源的分离株在与抗真菌药物耐药性相关的常见基因中显示出与人类分离株相似的杂合性缺失。我们的研究表明，环境中杀菌剂的使用可能会对感染动物的[物种名称未给出]施加选择压力，从而导致潜在耐药菌株在不同宿主之间传播。
