Satija Kshitij, Anjankar Vaibhav P
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Anatomy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Jan 31;16(1):e53276. doi: 10.7759/cureus.53276. eCollection 2024 Jan.
Due to their propensity for causing diarrheal illnesses and their rising susceptibility to antimicrobials, Shigella infections constitute a serious threat to global public health. This extensive study explores the frequency, antibiotic resistance, genetic evolution, and effects of Shigella infections on vulnerable groups. The research covers a wide range of geographical areas and sheds information on how the prevalence of Shigella species is evolving. Shigella strain antimicrobial resistance patterns are thoroughly examined. Multidrug resistance (MDR) has been found to often occur in investigations, especially when older antimicrobials are used. The improper use of antibiotics in China is blamed for the quick emergence of resistance, and variations in resistance rates have been seen across different geographical areas. Shigella strains' genetic makeup can be used to identify emerging trends and horizontal gene transfer's acquisition of resistance genes. Notably, S. sonnei exhibits the capacity to obtain resistance genes from nearby bacteria, increasing its capacity for infection. The study also emphasizes the difficulties in accurately serotyping Shigella strains due to inconsistencies between molecular and conventional serology. These results highlight the necessity of reliable diagnostic methods for monitoring Shigella infections. In conclusion, this study emphasizes how dynamic Shigella infections are, with varying patterns of occurrence, changing resistance landscapes, and genetic adaptability. In addition to tackling the rising problem of antibiotic resistance in Shigella infections, these findings are essential for guiding efforts for disease surveillance, prevention, and treatment.
由于志贺氏菌容易引发腹泻疾病且对抗菌药物的敏感性不断上升，志贺氏菌感染对全球公共卫生构成了严重威胁。这项广泛的研究探讨了志贺氏菌感染的频率、抗生素耐药性、基因进化以及对弱势群体的影响。该研究覆盖了广泛的地理区域，并揭示了志贺氏菌属流行情况的演变。对志贺氏菌菌株的抗菌药物耐药模式进行了全面检查。研究发现多重耐药（MDR）在调查中经常出现，尤其是在使用较老的抗菌药物时。中国抗生素的不当使用被认为是耐药性迅速出现的原因，不同地理区域的耐药率也存在差异。志贺氏菌菌株的基因组成可用于识别新出现的趋势以及水平基因转移获得耐药基因的情况。值得注意的是，宋内志贺氏菌表现出从附近细菌获取耐药基因的能力，从而增强了其感染能力。该研究还强调了由于分子血清学和传统血清学之间的不一致，准确对志贺氏菌菌株进行血清分型存在困难。这些结果凸显了采用可靠诊断方法监测志贺氏菌感染的必要性。总之，这项研究强调了志贺氏菌感染的动态性，包括不同的发生模式、不断变化的耐药情况和基因适应性。除了解决志贺氏菌感染中抗生素耐药性不断上升的问题外，这些发现对于指导疾病监测、预防和治疗工作也至关重要。
