Universidad de Buenos Aires, Instituto de Ingeniería Biomédica, Buenos Aires, Argentina.
Estudios en Neurociencias y Sistemas Complejos, CONICET, Buenos Aires, Argentina.
Sci Rep. 2024 Mar 4;14(1):5355. doi: 10.1038/s41598-024-56045-x.
Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in the transitions among different levels of consciousness remains as one of the greatest challenges in neuroscience. In this study we use a measure of integrated information (Φ) to evaluate dynamic changes during consciousness transitions. We applied the measure to intracranial electroencephalography (SEEG) recordings collected from 6 patients that suffer from refractory epilepsy, taking into account inter-ictal, pre-ictal and ictal periods. We analyzed the dynamical evolution of Φ in groups of electrode contacts outside the epileptogenic region and compared it with the Consciousness Seizure Scale (CCS). We show that changes on Φ are significantly correlated with changes in the reported states of consciousness.
意识是人类经验中最复杂的方面之一。研究不同意识水平之间的转变所涉及的机制仍然是神经科学面临的最大挑战之一。在这项研究中，我们使用整合信息（Φ）的度量来评估意识转变过程中的动态变化。我们将该度量应用于从 6 名患有难治性癫痫的患者采集的颅内脑电图（SEEG）记录中，考虑了发作间期、发作前期和发作期。我们分析了癫痫区域外电极接触组的 Φ的动态演化，并将其与意识发作量表（CCS）进行了比较。我们表明，Φ 的变化与报告的意识状态的变化显著相关。
