ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru, 560064, India.
ICAR-National Research Centre on Mithun, Medziphema, Chumukedima, Nagaland, 797106, India.
Arch Virol. 2024 Mar 7;169(3):65. doi: 10.1007/s00705-024-05996-7.
Lumpy skin disease (LSD) is a disease of cattle that is also known to cause mild infection in buffaloes. To date, there have been no reports of LSD in mithun (Bos frontalis), a bovine species distributed in Northeast India, Bangladesh, Myanmar, and parts of China. In the present study, the presence of typical clinical signs, virus isolation, PCR amplification, sequence analysis, and the demonstration of antibodies in serum by indirect enzyme-linked immunosorbent assay and serum neutralization test, confirmed the occurrence of LSD in mithun for the first time in India. Phylogenetic analysis based on the full-length RPO30 and P32 genes of LSD virus from mithun and cattle revealed 100% sequence identity, indicating circulation of the same strain in both species in India and the possibility of spillover between species.
牛结节疹病（LSD）是一种牛病，也已知会导致水牛轻度感染。迄今为止，在分布于印度东北部、孟加拉国、缅甸和中国部分地区的野牛物种耗牛（Bos frontalis）中，尚未有 LSD 的报告。在本研究中，通过典型临床症状的出现、病毒分离、PCR 扩增、序列分析以及间接酶联免疫吸附试验和血清中和试验检测血清中的抗体，首次在印度确认了耗牛中存在 LSD。基于耗牛和牛的 LSD 病毒全长 RPO30 和 P32 基因的系统进化分析显示，100%的序列同一性表明，在印度，这两种物种中存在相同的病毒株，并且物种间存在溢出的可能性。
