Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, 1000 North Oak Avenue ML2, Marshfield, WI, 54449, USA.
Influenza Division, US Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop H24-7, Atlanta, GA, 30329, USA.
BMC Infect Dis. 2024 Mar 8;24(1):300. doi: 10.1186/s12879-024-09108-3.
Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination.
Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness onset at three US Flu Vaccine Effectiveness Network sites were tested for SARS-CoV-2 by molecular assay. Enrollees completed an enrollment questionnaire and two follow-up surveys (7-24 days and 2-7 months after illness onset) online or by phone to assess illness characteristics and health status. The second follow-up survey included questions measuring global health, physical function, fatigue, and dyspnea. Scores in the four domains were compared by participants' SARS-CoV-2 test results in univariate analysis and multivariable Gamma regression.
During September 22, 2020 - February 13, 2021, 2712 eligible adults were enrolled, 1541 completed the first follow-up survey, and 650 completed the second follow-up survey. SARS-CoV-2-positive participants were more likely to report fever at acute illness but were otherwise comparable to SARS-CoV-2-negative participants. At first follow-up, SARS-CoV-2-positive participants were less likely to have reported fully or mostly recovered from their illness compared to SARS-CoV-2-negative participants. At second follow-up, no differences by SARS-CoV-2 test results were detected in the four domains in the multivariable model.
Self-reported disability was similar among outpatient SARS-CoV-2-positive and -negative adults 2-7 months after illness onset.
COVID-19 的症状，包括疲劳和呼吸困难，在 SARS-CoV-2 感染后可能会持续数周到数月。本研究比较了在广泛接种 COVID-19 疫苗之前因轻度至中度类似 COVID-19 疾病而就诊的 SARS-CoV-2 阳性和阴性患者的自我报告残疾情况。
在三个美国流感疫苗效力网络站点，在疾病发病后 10 天内，未接种疫苗且患有类似 COVID-19 疾病的成年人通过分子检测进行 SARS-CoV-2 检测。参与者在发病后 7-24 天和 2-7 个月完成了两次在线或电话随访调查，以评估疾病特征和健康状况。第二次随访调查包括评估全球健康、身体功能、疲劳和呼吸困难的问题。在单变量分析和多变量 Gamma 回归中，根据参与者的 SARS-CoV-2 检测结果比较了四个领域的评分。
在 2020 年 9 月 22 日至 2021 年 2 月 13 日期间，有 2712 名符合条件的成年人入组，1541 名完成了第一次随访调查，650 名完成了第二次随访调查。SARS-CoV-2 阳性参与者在急性疾病时更有可能报告发热，但在其他方面与 SARS-CoV-2 阴性参与者相似。在第一次随访时，SARS-CoV-2 阳性参与者报告完全或大部分从疾病中康复的比例低于 SARS-CoV-2 阴性参与者。在第二次随访时，在多变量模型中，四个领域的 SARS-CoV-2 检测结果无差异。
在疾病发病后 2-7 个月，门诊 SARS-CoV-2 阳性和阴性成年人的自我报告残疾情况相似。
