• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Grand challenges in organoid and organ-on-a-chip technologies.

作者信息

Skardal Aleksander

机构信息

Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH, United States.

Center for Cancer Engineering, The Ohio State University, Columbus, OH, United States.

出版信息

Front Bioeng Biotechnol. 2024 Feb 22;12:1366280. doi: 10.3389/fbioe.2024.1366280. eCollection 2024.

DOI:10.3389/fbioe.2024.1366280
PMID:38456004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919399/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/412f/10919399/4c3b526d68ea/fbioe-12-1366280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/412f/10919399/4c3b526d68ea/fbioe-12-1366280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/412f/10919399/4c3b526d68ea/fbioe-12-1366280-g001.jpg

相似文献

1
Grand challenges in organoid and organ-on-a-chip technologies.类器官和芯片器官技术的重大挑战。
Front Bioeng Biotechnol. 2024 Feb 22;12:1366280. doi: 10.3389/fbioe.2024.1366280. eCollection 2024.
2
Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling.用于药物筛选和疾病建模的芯片上类器官和芯片上人体系统。
Drug Discov Today. 2016 Sep;21(9):1399-1411. doi: 10.1016/j.drudis.2016.07.003. Epub 2016 Jul 12.
3
Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank.精准医学中的患者来源类器官:药物筛选、芯片类器官和活体类器官生物样本库。
Front Oncol. 2021 Dec 30;11:762184. doi: 10.3389/fonc.2021.762184. eCollection 2021.
4
Biomaterial-guided stem cell organoid engineering for modeling development and diseases.生物材料引导的干细胞类器官工程用于发育和疾病建模。
Acta Biomater. 2021 Sep 15;132:23-36. doi: 10.1016/j.actbio.2021.01.026. Epub 2021 Jan 22.
5
Biomaterials for intestinal organoid technology and personalized disease modeling.用于肠道类器官技术和个性化疾病建模的生物材料。
Acta Biomater. 2021 Sep 15;132:272-287. doi: 10.1016/j.actbio.2021.05.010. Epub 2021 May 20.
6
From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications.从芯片上器官到芯片上人类:研究进展与最新应用综述。
ACS Sens. 2024 Jul 26;9(7):3466-3488. doi: 10.1021/acssensors.4c00004. Epub 2024 Jul 11.
7
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance.微血管化肿瘤芯片类器官:推进具有病理生理相关性的临床前药物筛选
Nano Converg. 2021 Apr 13;8(1):12. doi: 10.1186/s40580-021-00261-y.
8
Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease.类器官和器官芯片系统:用于模拟神经和胃肠道疾病的新范式。
Curr Stem Cell Rep. 2017 Jun;3(2):98-111. doi: 10.1007/s40778-017-0080-x. Epub 2017 Apr 18.
9
Engineering vascularised organoid-on-a-chip: strategies, advances and future perspectives.工程化血管化芯片类器官:策略、进展与未来展望
Biomater Transl. 2024 Mar 28;5(1):21-32. doi: 10.12336/biomatertransl.2024.01.003. eCollection 2024.
10
Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy.肿瘤类器官:在癌症治疗中的协同应用、当前挑战与未来前景。
Cancer Commun (Lond). 2021 Dec;41(12):1331-1353. doi: 10.1002/cac2.12224. Epub 2021 Oct 29.

引用本文的文献

1
Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?用于药物筛选的生物打印:是减少动物实验的途径还是重新定义临床前研究?
Bioact Mater. 2025 Jul 15;51:993-1017. doi: 10.1016/j.bioactmat.2025.07.006. eCollection 2025 Sep.
2
Patient-derived organotypic tumor spheroids, tumoroids, and organoids: advancing immunotherapy using state-of-the-art 3D tumor model systems.患者来源的器官型肿瘤球体、类肿瘤和类器官:利用先进的3D肿瘤模型系统推进免疫治疗。
Lab Chip. 2025 Jun 24;25(13):3038-3059. doi: 10.1039/d5lc00062a.
3
Bioengineering ethics for the age of microphysiological systems.

本文引用的文献

1
A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity.用于药物反应和基质金属蛋白酶活性临床前建模的 3D 肾上腺皮质癌肿瘤平台。
Sci Rep. 2023 Sep 19;13(1):15508. doi: 10.1038/s41598-023-42659-0.
2
Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting.超越动物模型:利用3D体外类器官、微流控芯片和生物打印技术革新神经退行性疾病建模
Cell Tissue Res. 2023 Oct;394(1):75-91. doi: 10.1007/s00441-023-03821-2. Epub 2023 Aug 12.
3
Application of immune enhanced organoids in modeling personalized Merkel cell carcinoma research.
微生理系统时代的生物工程伦理
Front Bioeng Biotechnol. 2025 Mar 20;13:1497060. doi: 10.3389/fbioe.2025.1497060. eCollection 2025.
4
Targeted Cancer Therapy-on-A-Chip.靶向癌症治疗芯片
Adv Healthc Mater. 2024 Nov;13(29):e2400833. doi: 10.1002/adhm.202400833. Epub 2024 Aug 5.
免疫增强类器官在个体化 Merkel 细胞癌研究模型中的应用。
Sci Rep. 2022 Aug 16;12(1):13865. doi: 10.1038/s41598-022-17921-6.
4
Tumor cell-conditioned media drives collagen remodeling via fibroblast and pericyte activation in an premetastatic niche model.在转移前生态位模型中,肿瘤细胞条件培养基通过成纤维细胞和周细胞激活驱动胶原蛋白重塑。
iScience. 2022 Jun 19;25(7):104645. doi: 10.1016/j.isci.2022.104645. eCollection 2022 Jul 15.
5
Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications.个体化转化研究用肿瘤类器官: 将手术室与罕见癌症研究和临床意义相结合
Ann Surg Oncol. 2022 Nov;29(12):7354-7367. doi: 10.1245/s10434-022-12086-y. Epub 2022 Jul 3.
6
A multi-organ chip with matured tissue niches linked by vascular flow.一种具有通过血管流动连接的成熟组织微环境的多器官芯片。
Nat Biomed Eng. 2022 Apr;6(4):351-371. doi: 10.1038/s41551-022-00882-6. Epub 2022 Apr 27.
7
Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids.仿生水凝胶支持患者来源的乳腺肿瘤类器官的起始和生长。
Nat Commun. 2022 Mar 18;13(1):1466. doi: 10.1038/s41467-022-28788-6.
8
Biocompatibility pathways and mechanisms for bioactive materials: .生物活性材料的生物相容性途径及机制:
Bioact Mater. 2021 Aug 26;10:306-322. doi: 10.1016/j.bioactmat.2021.08.014. eCollection 2022 Apr.
9
Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate.“立方体内的身体”:一种用于多组织共培养的微生理系统,使用接近生理量的血液替代物。
Microphysiol Syst. 2020 Jun;4. doi: 10.21037/mps-19-8.
10
3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications.用于高通量筛选的3D生物打印:药物筛选、疾病建模及精准医学应用
Appl Phys Rev. 2019 Mar;6(1). doi: 10.1063/1.5056188. Epub 2019 Feb 6.