Wang Jie, Zhao Wenfeng, Wang Huang, Leng Haixia, Xue Qing, Peng Mao, Min Baoquan, Jin Xiukun, Tan Liucen, Gao Keming, Wang Hongxing
Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Gen Psychiatr. 2024 Mar 8;37(2):e101338. doi: 10.1136/gpsych-2023-101338. eCollection 2024.
Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.
To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.
Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.
The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.
Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.
尽管15毫安经颅交流电刺激（tACS）对抑郁症有治疗作用，但导致这种tACS配置产生疗效的人脑结构激活情况仍 largely未知。
研究在人脑通过前额和乳突电极施加77.5赫兹、15毫安的tACS时，哪些颅内脑结构会被激活。
利用8名未服用过药物的首发重度抑郁症门诊志愿者的磁共振成像构建真实的人体头部模型，然后用SimNIBS软件进行电场分布计算。
矢状面、冠状面和轴位面的电场分布显示，15毫安tACS程序可明显刺激双侧额叶、双侧颞叶、海马体、扣带回、下丘脑、丘脑、杏仁核、小脑和脑干。
包括皮层、皮层下结构、小脑和脑干在内的全脑激活参与了首发重度抑郁症的15毫安tACS干预。我们的结果表明，多个脑区同时参与可能是其减轻抑郁症状有效性的一种机制。
