O'Rourke Allison
George Mason University (Graduated), 4400 University Drive, Fairfax, VA, 22030, USA.
Trop Dis Travel Med Vaccines. 2024 Mar 15;10(1):6. doi: 10.1186/s40794-023-00215-8.
Hepatitis B and C virus, Opisthorchis viverrini and Clonorchis sinensis, are all individually known to put a person at increased risk for cholangiocarcinoma and hepatocellular carcinoma. This paper seeks to determine if there is any interaction between liver flukes and hepatitis virus infection that are known to put a person at an increased risk for cholangiocarcinoma and hepatocellular carcinoma collectively. This paper seeks to determine whether there is any publicly available articles in English that determine if having a hepatitis viral co-infection along with liver flukes would influence the risk of developing liver cancer. We followed PRISMA systematic review guidelines to conduct a literature review. Three manuscripts fit the search criteria. Two presented evidence in support of a synergistic relationship between liver fluke and viral hepatitis infection while the other found no relationship. One manuscript determined that the interaction between hepatitis B and C. sinensis did not have any significant risk of liver cancer. Studies found that HBV affected progression of co-infection to liver cancer but may have its own disease state worsened by presence of liver flukes. Only one paper was found that presented data on HCV, therefore no conclusion can be drawn due to the lack of evidence discovered. Of the studies, the conclusions and strength of the data were mixed. However, the stronger studies suggested a synergistic relationship between liver flukes and HBV to increase the risk of progressing to liver cancer.
已知乙型和丙型肝炎病毒、华支睾吸虫和中华肝吸虫都会使个体患胆管癌和肝细胞癌的风险增加。本文旨在确定已知会使个体患胆管癌和肝细胞癌风险增加的肝吸虫与肝炎病毒感染之间是否存在相互作用。本文旨在确定是否有任何英文公开文章探讨肝吸虫合并肝炎病毒感染是否会影响患肝癌的风险。我们遵循PRISMA系统评价指南进行文献综述。有三篇手稿符合检索标准。两篇提供了支持肝吸虫与病毒性肝炎感染之间存在协同关系的证据，而另一篇则未发现两者之间存在关系。一篇手稿确定乙型肝炎与中华肝吸虫之间的相互作用对肝癌没有任何显著风险。研究发现，乙肝病毒会影响合并感染向肝癌的进展，但肝吸虫的存在可能会使其自身病情恶化。仅发现一篇关于丙肝病毒的数据的论文，因此由于缺乏发现的证据无法得出结论。在这些研究中，结论和数据的力度参差不齐。然而，更有力的研究表明肝吸虫与乙肝病毒之间存在协同关系，会增加进展为肝癌的风险。
