College of Chemistry and Enviromental Science, Inner Mongolia Key Laboratory of Environmental Chemistry, Inner Mongolia Normal University, 81 zhaowudalu, Hohhot, 010022, China.
College of Pharmacy, Inner Mongolia Medical University, Jinchuankaifaqu, Hohhot, 010110, China.
Anal Bioanal Chem. 2024 Nov;416(27):5893-5914. doi: 10.1007/s00216-024-05240-w. Epub 2024 Mar 15.
Nanozymes are a class of nanomaterials with biocatalytic function and enzyme-like activity, whose advantages include high stability, low cost, and mass production. They can catalyze the substrates of natural enzymes based on specific nanostructures and serve as substitutes for natural enzymes. Their applied research involves a wide range of fields such as biomedicine, environmental governance, agriculture, and food. Molecular logic gates are a new cross-disciplinary discipline, which can simulate the function of silicon circuits on a molecular scale, perform single or multiple input logic operations, and generate logic outputs. A molecular logic gate is a binary operation that converts an input signal into an output signal according to the rules of Boolean logic, generating two signals, a high level, and a low level. The high and low levels represent the "true" and "false" values of the logic gates, and their outputs correspond to "l" and "0" of the molecular logic gates, respectively. The combination of nanozymes and logic gates is a novel and attractive research direction, and the cross-application of the two brings new opportunities and ideas for various fields, such as the construction of efficient biocomputers, intelligent drug delivery systems, and the precise diagnosis of diseases. This review describes the application of logic gates based on nanozymes, which is expected to provide a certain theoretical foundation for researchers' subsequent studies.
纳米酶是一类具有生物催化功能和类酶活性的纳米材料，其优点包括稳定性高、成本低、可大规模生产等。它们可以基于特定的纳米结构来催化天然酶的底物，作为天然酶的替代品。其应用研究涉及生物医学、环境治理、农业和食品等多个领域。分子逻辑门是一门新兴的交叉学科，可以在分子尺度上模拟硅电路的功能，进行单输入或多输入逻辑运算，并产生逻辑输出。分子逻辑门是一种根据布尔逻辑规则将输入信号转换为输出信号的二进制操作，产生两个信号，高电平（High）和低电平（Low）。高电平和低电平分别代表逻辑门的“真”和“假”值，其输出分别对应分子逻辑门的“1”和“0”。纳米酶和逻辑门的结合是一个新颖而有吸引力的研究方向，两者的交叉应用为各个领域带来了新的机遇和思路，例如高效生物计算机的构建、智能药物传递系统和疾病的精确诊断等。本文综述了基于纳米酶的逻辑门的应用，有望为研究人员后续的研究提供一定的理论基础。
