• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibition of oxidized low-density lipoprotein with orticumab inhibits coronary inflammation and reduces residual inflammatory risk in psoriasis: a pilot randomized, double-blind placebo-controlled trial.

作者信息

Farina Christopher J, Davidson Michael H, Shah Prediman K, Stark Charles, Lu Wenqi, Shirodaria Cheerag, Wright Timothy, Antoniades Charalambos A, Nilsson Jan, Mehta Nehal N

机构信息

Abcentra, 1925 Century Park E #1700, Los Angeles, CA 90067, USA.

Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.

出版信息

Cardiovasc Res. 2024 May 29;120(7):678-680. doi: 10.1093/cvr/cvae057.

DOI:10.1093/cvr/cvae057
PMID:38523341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11135636/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa93/11135636/1024e2fa28bd/cvae057f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa93/11135636/1024e2fa28bd/cvae057f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa93/11135636/1024e2fa28bd/cvae057f1.jpg

相似文献

1
Inhibition of oxidized low-density lipoprotein with orticumab inhibits coronary inflammation and reduces residual inflammatory risk in psoriasis: a pilot randomized, double-blind placebo-controlled trial.用奥替库单抗抑制氧化型低密度脂蛋白可抑制银屑病患者的冠状动脉炎症并降低残余炎症风险：一项随机、双盲、安慰剂对照的先导性试验。
Cardiovasc Res. 2024 May 29;120(7):678-680. doi: 10.1093/cvr/cvae057.
2
Orticumab: the potential to harness oxidized LDL to reduce coronary inflammation with plaque-targeted therapy.奥特西单抗：通过斑块靶向治疗利用氧化型低密度脂蛋白减少冠状动脉炎症的潜力。
Curr Opin Lipidol. 2025 Aug 1;36(4):170-178. doi: 10.1097/MOL.0000000000000990. Epub 2025 May 2.
3
Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial.两种银屑病治疗方法对血管炎症和新型炎症性心血管生物标志物的影响：一项随机安慰剂对照试验。
Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394. doi: 10.1161/CIRCIMAGING.117.007394.
4
Oral granulated Chinese herbal medicine (YXBCM01) plus topical calcipotriol for psoriasis vulgaris: study protocol for a double-blind, randomized placebo controlled trial.口服中药颗粒剂（YXBCM01）联合外用卡泊三醇治疗寻常型银屑病：一项双盲、随机、安慰剂对照试验的研究方案
Trials. 2014 Dec 19;15:495. doi: 10.1186/1745-6215-15-495.
5
Hydroxytyrosol supplementation improves antioxidant and anti-inflammatory status in individuals with overweight and prediabetes: A randomized, double-blind, placebo-controlled parallel trial.补充羟基酪醇可改善超重和糖尿病前期个体的抗氧化和抗炎状态：一项随机、双盲、安慰剂对照平行试验。
Clin Nutr. 2025 Sep;52:17-26. doi: 10.1016/j.clnu.2025.07.006. Epub 2025 Jul 12.
6
Treatment of Plaque Psoriasis with Guselkumab Reduces Systemic Inflammatory Burden as Measured by Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Monocyte/Lymphocyte Ratio: A post hoc Analysis of Three Randomised Clinical Trials.用古塞库单抗治疗斑块状银屑病可降低以中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值和单核细胞/淋巴细胞比值衡量的全身炎症负担：三项随机临床试验的事后分析
Dermatology. 2025 Apr 10:1-15. doi: 10.1159/000545148.
7
Efficacy and safety of ongericimab in Chinese statin-intolerant patients with primary hypercholesterolemia or mixed dyslipidemia: a randomized, placebo-controlled phase 3 trial.昂戈瑞西单抗在中国他汀不耐受的原发性高胆固醇血症或混合性血脂异常患者中的疗效和安全性：一项随机、安慰剂对照的3期试验。
Atherosclerosis. 2025 Jun 16;407:120408. doi: 10.1016/j.atherosclerosis.2025.120408.
8
Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial.吡咯烷二硫代氨基甲酸盐对 HIV 患者冠心病及炎症生物标志物的影响：REPRIEVE 随机临床试验的机制亚研究。
JAMA Cardiol. 2024 Apr 1;9(4):323-334. doi: 10.1001/jamacardio.2023.5661.
9
Effect of Extended-Release Niacin on High-Density Lipoprotein (HDL) Functionality, Lipoprotein Metabolism, and Mediators of Vascular Inflammation in Statin-Treated Patients.缓释烟酸对他汀治疗患者高密度脂蛋白（HDL）功能、脂蛋白代谢及血管炎症介质的影响。
J Am Heart Assoc. 2015 Sep 15;4(9):e001508. doi: 10.1161/JAHA.114.001508.
10
The Effects of Colchicine on Lipoprotein(a) and Oxidized Phospholipid Associated Cardiovascular Disease Risk.秋水仙碱对脂蛋白（a）及氧化磷脂相关心血管疾病风险的影响。
Eur J Prev Cardiol. 2024 Oct 30. doi: 10.1093/eurjpc/zwae355.

引用本文的文献

1
Post-Translational Modifications of Lipoproteins: Emerging Players Linking Inflammation and Cardiovascular Disease in Rheumatoid Arthritis-A Narrative Review.脂蛋白的翻译后修饰：类风湿关节炎中连接炎症与心血管疾病的新兴因素——一篇叙述性综述
Int J Mol Sci. 2025 Sep 2;26(17):8514. doi: 10.3390/ijms26178514.
2
Harnessing Statistical and Machine Learning Approaches to Analyze Oxidized LDL in Clinical Research.利用统计和机器学习方法在临床研究中分析氧化型低密度脂蛋白。
Cell Biochem Biophys. 2025 Aug 30. doi: 10.1007/s12013-025-01837-9.
3
The Perivascular Fat Attenuation Index: Bridging Inflammation and Cardiovascular Disease Risk.

本文引用的文献

1
Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers.血管周脂肪组织作为治疗靶点和临床生物标志物的来源。
Eur Heart J. 2023 Oct 12;44(38):3827-3844. doi: 10.1093/eurheartj/ehad484.
2
Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.炎症和胆固醇作为接受他汀类药物治疗患者心血管事件的预测因素：三项随机试验的联合分析
Lancet. 2023 Apr 15;401(10384):1293-1301. doi: 10.1016/S0140-6736(23)00215-5. Epub 2023 Mar 6.
3
Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device.
血管周围脂肪衰减指数：连接炎症与心血管疾病风险
J Clin Med. 2025 Jul 4;14(13):4753. doi: 10.3390/jcm14134753.
4
Damage-associated molecular patterns (DAMPs) in vascular diseases.血管疾病中的损伤相关分子模式（DAMPs）
J Biol Chem. 2025 May 15;301(6):110241. doi: 10.1016/j.jbc.2025.110241.
5
Orticumab: the potential to harness oxidized LDL to reduce coronary inflammation with plaque-targeted therapy.奥特西单抗：通过斑块靶向治疗利用氧化型低密度脂蛋白减少冠状动脉炎症的潜力。
Curr Opin Lipidol. 2025 Aug 1;36(4):170-178. doi: 10.1097/MOL.0000000000000990. Epub 2025 May 2.
6
Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?接种疫苗作为减轻心血管风险的一种有前景的方法：我们准备好接受疫苗策略了吗？
Biomolecules. 2024 Dec 20;14(12):1637. doi: 10.3390/biom14121637.
7
Emerging Imaging Techniques for Atherosclerosis in Systemic Immune-Mediated Inflammatory Conditions.系统性免疫介导炎症性疾病中动脉粥样硬化的新兴成像技术
Arterioscler Thromb Vasc Biol. 2025 Jan;45(1):11-22. doi: 10.1161/ATVBAHA.124.321202. Epub 2024 Nov 14.
8
Perivascular Fat: A Novel Risk Factor for Coronary Artery Disease.血管周围脂肪：冠状动脉疾病的一种新危险因素。
Diagnostics (Basel). 2024 Aug 22;14(16):1830. doi: 10.3390/diagnostics14161830.
9
Inflammation and Atherosclerosis: Prospects for Clinical Trials.炎症与动脉粥样硬化：临床试验前景
Arterioscler Thromb Vasc Biol. 2024 Sep;44(9):1899-1905. doi: 10.1161/ATVBAHA.124.320155. Epub 2024 Aug 21.
10
Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis.颠覆传统：动脉粥样硬化中的抗动脉粥样硬化 IgM 产生 B 细胞。
Arterioscler Thromb Vasc Biol. 2024 Sep;44(9):1906-1915. doi: 10.1161/ATVBAHA.124.319847. Epub 2024 Jul 18.
采用心血管计算机断层扫描对冠状动脉炎症进行标准化测量：作为一种预后医疗设备融入临床护理。
Cardiovasc Res. 2021 Nov 22;117(13):2677-2690. doi: 10.1093/cvr/cvab286.
4
Cardiovascular Risk in Patients With Psoriasis: JACC Review Topic of the Week.银屑病患者的心血管风险：JACC 本周综述主题。
J Am Coll Cardiol. 2021 Apr 6;77(13):1670-1680. doi: 10.1016/j.jacc.2021.02.009.
5
Targeting cardiovascular inflammation: next steps in clinical translation.靶向心血管炎症：临床转化的下一步
Eur Heart J. 2021 Jan 1;42(1):113-131. doi: 10.1093/eurheartj/ehaa099.
6
Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index.生物制剂治疗与银屑病患者冠状动脉炎症的相关性：基于血管周围脂肪衰减指数的评估。
JAMA Cardiol. 2019 Sep 1;4(9):885-891. doi: 10.1001/jamacardio.2019.2589.
7
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.使用计算机断层扫描技术无创性检测冠状动脉炎症及预测残余心血管风险（CRISP CT 研究）：前瞻性结局数据的事后分析。
Lancet. 2018 Sep 15;392(10151):929-939. doi: 10.1016/S0140-6736(18)31114-0. Epub 2018 Aug 28.
8
Detecting human coronary inflammation by imaging perivascular fat.通过对血管周围脂肪进行成像来检测人类冠状动脉炎症。
Sci Transl Med. 2017 Jul 12;9(398). doi: 10.1126/scitranslmed.aal2658.
9
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques.靶向氧化型 LDL 可改善肥胖恒河猴的胰岛素敏感性和免疫细胞功能。
Mol Metab. 2013 Jun 11;2(3):256-69. doi: 10.1016/j.molmet.2013.06.001. eCollection 2013.
10
Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis.氧化特异性表位与免疫应答：动脉粥样硬化的转化生物治疗学意义。
Curr Opin Pharmacol. 2013 Apr;13(2):168-79. doi: 10.1016/j.coph.2013.02.005. Epub 2013 Mar 28.