College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Anim Biotechnol. 2024 Nov;35(1):2331640. doi: 10.1080/10495398.2024.2331640. Epub 2024 Mar 25.
The present study was carried out to evaluate the effects of dietary vitamin E (VE) or grape seed extract (GSE) on the growth performance and antioxidant function of broilers. Two hundred sixteen broiler chicks were randomly assigned to 3 diets: diet supplemented with oxidized rice bran oil (CN group), CN group with 25 mg/kg VE or 100 mg/kg GSE. Dietary VE or GSE improved the growth performance, reverted the disturbed levels of liver antioxidant enzymes, and reduced liver damage of broilers fed oxidized rice bran oil. The mRNA data showed that supplementation of VE or GSE enhanced the antioxidant capacity of the broiler liver through activation of the Keap1-Nrf2/ARE signaling pathway. The results suggested that VE and GSE can increase weight gain, improve the oxidative status, and alleviate liver injury in broiler chicken fed oxidized rice bran oil.
本研究旨在评估日粮维生素 E（VE）或葡萄籽提取物（GSE）对肉鸡生长性能和抗氧化功能的影响。将 216 只肉鸡雏鸡随机分配到 3 种日粮中：添加氧化米糠油的日粮（CN 组）、添加 25mg/kg VE 或 100mg/kg GSE 的 CN 组。日粮 VE 或 GSE 可改善生长性能，使受氧化米糠油干扰的肝脏抗氧化酶水平恢复正常，并减轻肉鸡的肝损伤。mRNA 数据表明，VE 和 GSE 通过激活 Keap1-Nrf2/ARE 信号通路增强了肉鸡肝脏的抗氧化能力。结果表明，VE 和 GSE 可增加肉鸡的体重增加，改善氧化状态，并减轻氧化米糠油喂养的肉鸡的肝损伤。
