Health-related quality of life (HRQoL) is the most important patient-reported outcome in clinical trials and patient care. HRQoL is further considered as target variable in treatment guidelines and as outcome indicator in the evaluation of the quality of care. Numerous validated questionnaires are available for the assessment of HRQoL from the perspective of patients with skin diseases. However, many are of inadequate methodological quality, indicating the need for further research in the development of high-quality measurement instruments. The implementation of routine electronic HRQoL assessments is a promising approach.