Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou University, Yangzhou 225009, China.
Genes (Basel). 2024 Feb 20;15(3):260. doi: 10.3390/genes15030260.
In order to investigate the effect of FecB on litter size and growth and development traits of Suhu meat sheep and the inheritance patterns of FecB between parents and offspring in the population. In this experiment, 2241 sheep from the Suhu meat sheep population were tested for FecB using capillary electrophoresis. We combined the lambing records of 473 ewes, the growth trait records of 881 sheep at both the birth and weaning (2-month-old) stages, and the complete genealogical records of 643 lambs to analysis the distribution of FecB in the Suhu meat sheep breeding population, its effect on litter size of ewes, growth and development of lambs, and the inheritance patterns of FecB. The results showed that there were three genotypes of FecB in the Suhu meat sheep population, namely the AA genotype, AG genotype, and GG genotype. FecB in this population has a moderate polymorphism (0.25 < < 0.5), and deviates from Hardy-Weinberg disequilibrium < 0.05). The litter size of GG genotype ewes was significantly higher than that with the AG and AA genotypes ( < 0.01). A Chi-square test showed that the inheritance patterns of FecB follows Mendel's Laws of Inheritance ( > 0.05). An association analysis of different genotypes of FecB with body weight and body size of Suhu meat sheep at birth and weaning revealed that FecB adversely affects the early growth and development of Suhu meat sheep. In summary, FecB can improve the litter size of ewes but it has negative effects on the early growth and survival rate of lambs in sheep. Therefore, FecB test results and feeding management measures should be comprehensively applied to improve the reproductive performance of ewes, the survival rate and production performance of lambs in sheep production, and thus improve the economic benefits of sheep farms.
为了研究 FecB 对苏沪肉羊产羔数和生长发育性状的影响及其在群体中父母与后代之间的遗传模式。本实验采用毛细管电泳法对苏沪肉羊群体中的 2241 只绵羊进行了 FecB 检测。结合 473 只母羊的产羔记录、881 只绵羊在出生和断奶（2 月龄）阶段的生长性状记录以及 643 只羔羊的完整系谱记录，分析了 FecB 在苏沪肉羊育种群中的分布、对母羊产羔数、羔羊生长发育的影响以及 FecB 的遗传模式。结果表明，苏沪肉羊群体中存在 FecB 的 3 种基因型，即 AA 基因型、AG 基因型和 GG 基因型。该群体中 FecB 具有中度多态性（0.25< <0.5），且偏离 Hardy-Weinberg 不平衡（<0.05）。GG 基因型母羊的产羔数显著高于 AG 和 AA 基因型（<0.01）。卡方检验表明，FecB 的遗传模式符合孟德尔遗传定律（>0.05）。不同 FecB 基因型与苏沪肉羊出生和断奶体重和体尺的关联分析表明，FecB 对苏沪肉羊的早期生长发育有不利影响。综上所述，FecB 可以提高母羊的产羔数，但对羔羊的早期生长和成活率有负面影响。因此，应综合应用 FecB 检测结果和饲养管理措施，以提高母羊的繁殖性能、羔羊的成活率和生产性能，从而提高羊场的经济效益。
