CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal.
ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Sci Rep. 2024 Mar 28;14(1):7354. doi: 10.1038/s41598-024-57761-0.
Immune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways between neuroendocrine and immune systems in European seabass (Dicentrarchus labrax). When tryptophan was supplemented in the diet of unstressed fish, it induced changes in the hypothalamic-pituitary-interrenal axis response to stress. Tryptophan-mediated effects were observed in the expression of anti-inflammatory cytokines and glucocorticoid receptors. Tryptophan supplementation decreased pro-opiomelanocortin b-like levels, that are related with adrenocorticotropic hormone and cortisol secretion. When stressed fish fed a tryptophan-supplemented diet were subjected to an inflammatory stimulus, plasma cortisol levels decreased and the expression of genes involved in the neuroendocrine response was altered. Modulatory effects of tryptophan dietary intervention on molecular patterns seem to be mediated by altered patterns in serotonergic activity.
免疫营养目前通过将功能性成分纳入水产饲料来增强鱼类健康。本研究旨在研究色氨酸营养与调节神经内分泌和免疫系统之间通讯途径的网络之间的联系在欧洲鲈鱼（Dicentrarchus labrax）中。当色氨酸在未应激鱼类的饮食中补充时，它会诱导下丘脑-垂体-肾上腺轴对应激的反应发生变化。色氨酸介导的作用表现在抗炎细胞因子和糖皮质激素受体的表达上。色氨酸补充降低了与促肾上腺皮质激素和皮质醇分泌有关的促黑激素原 b 样物质的水平。当应激时喂食色氨酸补充饮食的鱼类受到炎症刺激时，血浆皮质醇水平下降，并且涉及神经内分泌反应的基因的表达发生改变。色氨酸饮食干预对分子模式的调节作用似乎是通过改变 5-羟色胺能活性的模式来介导的。
