Chair and Department of Oral Medicine, Medical University, Lublin, Poland.
Department and Clinic of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland.
Ann Agric Environ Med. 2024 Mar 25;31(1):138-143. doi: 10.26444/aaem/169166. Epub 2023 Aug 15.
Lichen planus is a chronic inflammatory skin disease involving the mucous membrane of the oral cavity. It is postulated that different factors play a role in the occurrence of the disease and may activate the immune system, thus influencing the development of lichen planus. Vitamin D is a steroid prohormone with multiple systemic effects.
The aim of this study was to assess oral lichen planus against 25-hydroxy-vitamin D3 serum level. Vitamin D takes an active part in the pathogenesis of immunisation diseases, may have also a beneficial effect on oral health.
The clinical picture of lichen planus was analyzed according to the concentration of 25-hydroxy-vitamin D3. Patients were given a questionnaire interview which included questions about the co-existence of systemic diseases, subjective complaints, and information relating to the individual course of the disease. In the next stage of the study, patients were underwent a physical examination. Laboratory determinations of the concentration of 25-hydroxy-vitamin D3 were also performed.
The mean vitamin D concentration in patients with lichen planus in the oral cavity was 14.37 ± 4.95 ng/ml. An insufficient level (10-30 ng/ml) was detected in 84.91% of the examined patients, whereas a deficiency (< 10 ng/ml) was observed in 15.09% of those patients. None of the analyzed patients had vitamin D level in the range of established clinical standards. A substantially lowered vitamin D level was found in patients reporting bleeding and pain of the gums.
The study enhances relationship between reduced levels of vitamin D3 and lichen planus in patients with oral lesions. Thus, vitamin D3 control and supplementation may play an important role in the treatment of lichen planus.
扁平苔藓是一种慢性炎症性皮肤疾病，涉及口腔黏膜。据推测，不同的因素在疾病的发生中起作用，并可能激活免疫系统，从而影响扁平苔藓的发展。维生素 D 是一种具有多种全身作用的甾体前体激素。
本研究旨在评估口腔扁平苔藓与 25-羟维生素 D3 血清水平的关系。维生素 D 在免疫性疾病的发病机制中起着积极的作用，对口腔健康也可能有有益的影响。
根据 25-羟维生素 D3 的浓度分析扁平苔藓的临床图片。对患者进行问卷调查，包括关于共存的系统性疾病、主观症状和与疾病个体病程相关的信息。在研究的下一阶段，对患者进行了体格检查。还进行了 25-羟维生素 D3 浓度的实验室测定。
口腔扁平苔藓患者的平均维生素 D 浓度为 14.37 ± 4.95ng/ml。在检查的患者中，84.91%存在维生素 D 水平不足（10-30ng/ml），而 15.09%的患者存在缺乏症（<10ng/ml）。在分析的患者中，没有一个人的维生素 D 水平在既定的临床标准范围内。在报告牙龈出血和疼痛的患者中发现了维生素 D 水平显著降低。
该研究增强了维生素 D3 水平降低与口腔病变患者扁平苔藓之间的关系。因此，维生素 D3 的控制和补充可能在扁平苔藓的治疗中发挥重要作用。
