Feng Peipei, Luo Yang, Ke Chunhai, Qiu Haofeng, Wang Wei, Zhu Yabin, Hou Ruixia, Xu Long, Wu Songze
School of Medicine, Ningbo University, Ningbo, China.
Lihuili Hospital, Affiliated Hospital of Ningbo University, Ningbo, China.
Front Bioeng Biotechnol. 2021 Feb 18;9:650598. doi: 10.3389/fbioe.2021.650598. eCollection 2021.
Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels.
皮肤伤口不仅给患者带来身体疼痛，也是社会的经济负担。有必要寻找一种有效的方法来促进皮肤修复。水凝胶被认为是有效的伤口敷料。它们具有许多独特的特性，如生物相容性、生物可降解性、高吸水性和保水性等，因此是伤口愈合有前景的候选材料。壳聚糖是一种通过甲壳素脱乙酰化获得的聚合物生物材料。具有易于获取、抗菌和止血活性以及促进皮肤再生的能力，类似水凝胶的功能性伤口敷料（以壳聚糖及其衍生物为代表）因其在促进皮肤伤口修复中的有效性和作用机制而受到广泛关注。在本综述中，我们广泛讨论了基于壳聚糖的功能材料在伤口修复中促进止血、抗炎、肉芽组织增殖的机制。我们还提供了此类材料在伤口治疗中应用的最新信息。此外，我们总结了通过将其他化学成分、活性生物分子和其他物质掺入水凝胶中来增强壳聚糖优势并保持其固有性质的方法。
