Alvarado-Esquivel Cosme, Estrada-Martínez Sergio, Ramos-Nevarez Agar, Alvarado-Félix Ángel Osvaldo, Cerrillo-Soto Sandra Margarita, Alvarado-Félix Gustavo Alexis, Guido-Arreola Carlos Alberto, Saenz-Soto Leandro
1Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
2Institute for Scientific Research "Dr. Roberto Rivera-Damm", Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
Eur J Microbiol Immunol (Bp). 2024 Apr 2;14(2):180-184. doi: 10.1556/1886.2024.00025. Print 2024 May 14.
Abdominal pain has been rarely reported in individuals infected with Toxoplasma gondii (T. gondii). The aim of this study was to determine the association between T. gondii infection and abdominal pain. Two hundred and ninety-nine patients with abdominal pain (cases) and 299 age- and gender-matched people without abdominal pain (controls) were tested for anti-T. gondii IgG and IgM antibodies. Twenty-four (8.0%) of the 299 cases and 12 (4.0%) of the 299 controls were positive for anti-T. gondii IgG antibodies (OR: 2.08; 95% CI: 1.02-4.25; P = 0.03). The seroprevalence of T. gondii infection was significantly higher in women with frequent abdominal pain than in women without this clinical feature (OR: 2.30; 95% CI: 1.06-4.96; P = 0.02). Twelve (4.0%) of the 299 cases and 7 (2.3%) of the 299 controls had high (>150 IU mL-1) anti-T. gondii IgG antibody levels (OR: 1.74; 95% CI: 0.67-4.49; P = 0.24). Seven (29.2%) of the 24 cases with anti-T. gondii IgG antibodies and 3 (25.0%) of the 12 controls with anti-T. gondii IgG antibodies were positive to anti-T. gondii IgM antibodies (OR: 1.23; 95% CI: 0.25-5.97; P = 1.00). Results suggest an association between T. gondii infection and frequent abdominal pain. Further research to confirm this association should be conducted.
在感染刚地弓形虫的个体中，腹痛鲜有报道。本研究旨在确定刚地弓形虫感染与腹痛之间的关联。对299例腹痛患者（病例组）和299例年龄及性别匹配的无腹痛者（对照组）进行了抗刚地弓形虫IgG和IgM抗体检测。299例病例中有24例（8.0%）抗刚地弓形虫IgG抗体呈阳性，299例对照组中有12例（4.0%）呈阳性（比值比：2.08；95%置信区间：1.02 - 4.25；P = 0.03）。频繁腹痛女性的刚地弓形虫感染血清阳性率显著高于无此临床特征的女性（比值比：2.30；95%置信区间：1.06 - 4.96；P = 0.02）。299例病例中有12例（4.0%）抗刚地弓形虫IgG抗体水平高（>150 IU/mL），299例对照组中有7例（2.3%）（比值比：1.74；95%置信区间：0.67 - 4.49；P = 0.24）。24例抗刚地弓形虫IgG抗体阳性的病例中有7例（29.2%）抗刚地弓形虫IgM抗体呈阳性，12例抗刚地弓形虫IgG抗体阳性的对照组中有3例（25.0%）（比值比：1.23；95%置信区间：0.25 - 5.97；P = 1.00）。结果表明刚地弓形虫感染与频繁腹痛之间存在关联。应开展进一步研究以证实这种关联。
